Literature DB >> 15863336

Design, synthesis and structure-activity relationships of 6-O-arylpropargyl diazalides with potent activity against multidrug-resistant Streptococcus pneumoniae.

Hong Yong1, Yu Gui Gu, Richard F Clark, Thomas Marron, Zhenkun Ma, Niru Soni, Gregory G Stone, Angela M Nilius, Kennan Marsh, Stevan W Djuric.   

Abstract

A novel series of 6-O-arylpropargyl diazalides was synthesized and evaluated for their antibacterial activity. Members of this series exhibited potent activity against erythromycin-resistant respiratory tract pathogens.

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Year:  2005        PMID： 15863336     DOI： 10.1016/j.bmcl.2005.03.011

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

Review 1.  Modern Approaches for Asymmetric Construction of Carbon-Fluorine Quaternary Stereogenic Centers: Synthetic Challenges and Pharmaceutical Needs.

Authors:  Yi Zhu; Jianlin Han; Jiandong Wang; Norio Shibata; Mikiko Sodeoka; Vadim A Soloshonok; Jaime A S Coelho; F Dean Toste
Journal:  Chem Rev       Date:  2018-04-02       Impact factor: 60.622

2.  Synthesis and antibacterial activity of novel 11-[3-[(arylcarbamoyl)oxy]propylamino]-11-deoxy-6-O-methyl-3-oxoerythromycin A 11-N,12-O-cyclic carbamate derivatives.

Authors:  Zhonghui Zheng; Deping Du; Lili Cao; Jun Liu; Xiaofang Chen
Journal:  J Antibiot (Tokyo)       Date:  2016-04-27       Impact factor: 2.649

3.  Cellular uptake and cytotoxicity of drug-peptide conjugates regulated by conjugation site.

Authors:  Pengcheng Zhang; Andrew G Cheetham; Lye Lin Lock; Honggang Cui
Journal:  Bioconjug Chem       Date:  2013-03-26       Impact factor: 4.774
  3 in total

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