| Literature DB >> 15863328 |
Chung-Kyu Ryu1, Su-Kyung Lee, Ja-Young Han, Ok-Jai Jung, Jung Yoon Lee, Seong Hee Jeong.
Abstract
5-Arylamino-4,7-dioxobenzo[b]thiophenes 3-6 were synthesized and tested for in vitro antifungal activity against Candida and Aspergillus species. 5-Arylamino-6-chloro-2-(methoxycarbonyl)-4,7-dioxobenzo[b]thiophenes 5 showed, in general, more potent antifungal activity against Candida species than the other 4,7-dioxobenzo[b]thiophenes 3, 4 and 6. The results suggest that 5-arylamino-4,7-dioxobenzo[b]thiophenes would be potent antifungal agents.Entities:
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Year: 2005 PMID： 15863328 DOI： 10.1016/j.bmcl.2005.03.042
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823