Literature DB >> 15863315

3,3-Bisaryloxindoles as mineralocorticoid receptor antagonists.

David A Neel1, Matthew L Brown, Peter A Lander, Timothy A Grese, Jean M Defauw, Robert A Doti, Todd Fields, Sally Ann Kelley, Stephon Smith, Karen M Zimmerman, Mitchell I Steinberg, Prabhakar K Jadhav.   

Abstract

Syntheses and SAR studies of 3,3-bisaryloxindole analogues provided potent mineralocorticoid receptor (MR) antagonists that were selective over other steroid nuclear hormone receptors.

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Year:  2005        PMID： 15863315     DOI： 10.1016/j.bmcl.2005.03.086

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  Alpha-arylation of 3-aryloxindoles.

Authors:  Cheng-Kang Mai; Matthew F Sammons; Tarek Sammakia
Journal:  Org Lett       Date:  2010-05-21       Impact factor: 6.005

2.  Preparation of Aryl-Susbstituted 2-Oxyindoles by Superelectrophilic Chemistry.

Authors:  Rajasekhar Reddy Naredla; Erum K Raja; Douglas A Klumpp
Journal:  Tetrahedron Lett       Date:  2013-06-19       Impact factor: 2.415

3.  Discovery of benzimidazole oxazolidinediones as novel and selective nonsteroidal mineralocorticoid receptor antagonists.

Authors:  Christine Yang; Jaume Balsells; Hong D Chu; Jason M Cox; Alejandro Crespo; Xiuying Ma; Lisa Contino; Patricia Brown; Sheng Gao; Beata Zamlynny; Judyann Wiltsie; Joseph Clemas; JeanMarie Lisnock; Jack Gibson; Gaochao Zhou; Margarita Garcia-Calvo; Thomas J Bateman; Vincent Tong; Ling Xu; Martin Crook; Peter Sinclair; Hong C Shen
Journal:  ACS Med Chem Lett       Date:  2015-03-06       Impact factor: 4.345

Review 4.  Is there a new dawn for selective mineralocorticoid receptor antagonism?

Authors:  James M Luther
Journal:  Curr Opin Nephrol Hypertens       Date:  2014-09       Impact factor: 2.894

5.  Asymmetric synthesis of fully substituted cyclopentane-oxindoles through an organocatalytic triple Michael domino reaction.

Authors:  Liang-Hua Zou; Arne R Philipps; Gerhard Raabe; Dieter Enders
Journal:  Chemistry       Date:  2014-12-02       Impact factor: 5.236

6.  An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris.

Authors:  Kali R Iyer; Kaddy Camara; Martin Daniel-Ivad; Richard Trilles; Sheila M Pimentel-Elardo; Jen L Fossen; Karen Marchillo; Zhongle Liu; Shakti Singh; José F Muñoz; Sang Hu Kim; John A Porco; Christina A Cuomo; Noelle S Williams; Ashraf S Ibrahim; John E Edwards; David R Andes; Justin R Nodwell; Lauren E Brown; Luke Whitesell; Nicole Robbins; Leah E Cowen
Journal:  Nat Commun       Date:  2020-12-22       Impact factor: 14.919
  6 in total

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