| Literature DB >> 15863314 |
Mark P Wentland1, Xufeng Sun, Yigong Bu, Rongliang Lou, Dana J Cohen, Jean M Bidlack.
Abstract
8-Position variants of cyclazocine have been made where the phenolic 8-OH was replaced by thioamide, amidine, guanidine, urea and thiourea groups. High affinity for opioid receptors was observed for the 8-CSNH2 and 8-NHCHS analogues indicating that these groups are isosteric with not only the 8-OH but with the previously synthesized 8-CONH2 and 8-NHCHO cyclazocine derivatives.Entities:
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Year: 2005 PMID： 15863314 DOI： 10.1016/j.bmcl.2005.03.056
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823