| Literature DB >> 15863308 |
Zhiqiang Guo1, Yongsheng Chen, Charles Q Huang, Timothy D Gross, Joseph Pontillo, Martin W Rowbottom, John Saunders, Scott Struthers, Fabio C Tucci, Qiu Xie, Warren Wade, Yun-Fei Zhu, Dongpei Wu, Chen Chen.
Abstract
Uracil derivatives were designed and synthesized to avoid atropisomers observed in the 6-methyluracils as antagonists of the human GnRH receptor. Optimization at the 1- and 5-positions of the uracil resulted in potent compounds such as 24 (Ki=0.45 nM).Entities:
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Year: 2005 PMID： 15863308 DOI： 10.1016/j.bmcl.2005.03.057
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823