| Literature DB >> 15863300 |
Carlo Ballatore1, Simon E Aspland, Rosario Castillo, Joel Desharnais, Trisha Eustaquio, Chengzao Sun, Angelo J Castellino, Amos B Smith.
Abstract
A general protocol for the synthesis of paclitaxel C-10 carbamates is described. The method entails MeI-mediated activation of 2'-O-TBS-7-O-TES-10-O-deacetyl-paclitaxel-10-O-carbonylimidazole prior to reaction with amines. This method is effective for the synthesis of paclitaxel C-10 derivatives, including bifunctional molecules.Entities:
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Year: 2005 PMID： 15863300 DOI： 10.1016/j.bmcl.2005.03.072
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823