| Literature DB >> 15863293 |
Kun Liu1, Regina M Black, John J Acton, Ralph Mosley, Sheryl Debenham, Ramon Abola, Meng Yang, Richard Tschirret-Guth, Lawrence Colwell, Cherrie Liu, Margaret Wu, Chuanlin F Wang, Karen L MacNaul, Margaret E McCann, David E Moller, Joel P Berger, Peter T Meinke, A Brian Jones, Harold B Wood.
Abstract
A series of metabolically robust N-benzyl-indole selective PPARgamma modulators with either a 3-benzoyl or 3-benzisoxazoyl moiety have been identified. In vitro, these compounds are partial agonists and exhibit reduced adipogenesis in human adipocytes. In vivo, these SPPARgammaMs result in potent glucose lowering in db/db mice and attenuate increases in heart weight and brown adipose tissue that is typically observed in rats upon treatment with PPARgamma full agonists.Entities:
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Year: 2005 PMID： 15863293 DOI： 10.1016/j.bmcl.2005.03.092
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823