| Literature DB >> 15863292 |
Michelle Wright Valderas1, Rosemarie B Alcantara, John E Baumgartner, Bryan H Bellaire, Gregory T Robertson, Wai-Leung Ng, John M Richardson, Malcolm E Winkler, R Martin Roop.
Abstract
Two-dimensional gel electrophoretic analysis of cell lysates suggests that stationary phase production of wild-type levels of an ortholog of the low pH dependent chaperone HdeA in Brucella abortus 2308 during growth in a minimal medium requires the presence of the RNA binding protein Hfq. Although mutational analysis demonstrated that HdeA contributes to acid resistance in this bacterium, this protein is not required for wild-type virulence in the BALB/c mouse model. These experimental findings indicate that the brucellae rely upon additional gene products to resist the acidic conditions they encounter in the phagosomal compartment of host macrophages.Entities:
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Year: 2005 PMID： 15863292 DOI： 10.1016/j.vetmic.2005.01.018
Source DB: PubMed Journal: Vet Microbiol ISSN： 0378-1135 Impact factor: 3.293