| Literature DB >> 15863202 |
Jan Zuna1, Ondrej Krejci, Jozef Madzo, Eva Fronkova, Lucie Sramkova, Ondrej Hrusak, Tomas Kalina, Martina Vaskova, Jan Stary, Jan Trka.
Abstract
TEL/AML1 fusion gene is present in 20-25% of childhood acute lymphoblastic leukaemias. In order to unravel at which stage of B-cell precursor development the fusion is originated, we analysed frequency and pattern of immunoreceptor (immunoglobulin and T-cell receptor) gene rearrangements in 47 TEL/AML1-positive and 43 TEL/AML1-negative cases of the same CD10+ immunophenotype. Moreover, we compared corresponding immunoreceptor gene rearrangements in 11 cases of TEL/AML1-positive leukaemia at diagnosis and relapse. More mature immunogenotype of TEL/AML1-positive cases and changes in 37% of rearrangements between diagnosis and relapse suggest that in most cases the TEL/AML1 fusion is formed during immunoreceptor gene rearrangement process.Entities:
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Year: 2005 PMID： 15863202 DOI： 10.1016/j.leukres.2004.11.007
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156