OBJECTIVE: To analyze the role of hysterectomy, performed on benign indications, on the risk of developing ovarian cancer. METHODS: Multicenter case-control study conducted in four Italian areas. Cases were 1031 women with epithelial ovarian cancer. Controls were 2411 women admitted to the same network of hospitals for a wide spectrum of acute non-neoplastic conditions, unrelated to known risk factors for ovarian cancer. RESULTS: Compared to women with intact uterus and ovaries, the multivariate odds ratios (OR) was 0.6 (95% confidence interval 0.4-0.9) for women who reported hysterectomy. The OR was 0.5 > or =15 years after surgery. The OR was similar for women who had had pelvic surgery before age 45 and for those who had surgery later. No appreciable heterogeneity emerged across strata of parity and family history of ovarian/breast cancer. CONCLUSION: Women who had undergone hysterectomy had a long-term reduced risk of epithelial ovarian cancer.
OBJECTIVE: To analyze the role of hysterectomy, performed on benign indications, on the risk of developing ovarian cancer. METHODS: Multicenter case-control study conducted in four Italian areas. Cases were 1031 women with epithelial ovarian cancer. Controls were 2411 women admitted to the same network of hospitals for a wide spectrum of acute non-neoplastic conditions, unrelated to known risk factors for ovarian cancer. RESULTS: Compared to women with intact uterus and ovaries, the multivariate odds ratios (OR) was 0.6 (95% confidence interval 0.4-0.9) for women who reported hysterectomy. The OR was 0.5 > or =15 years after surgery. The OR was similar for women who had had pelvic surgery before age 45 and for those who had surgery later. No appreciable heterogeneity emerged across strata of parity and family history of ovarian/breast cancer. CONCLUSION:Women who had undergone hysterectomy had a long-term reduced risk of epithelial ovarian cancer.
Authors: Megan S Rice; Megan A Murphy; Allison F Vitonis; Daniel W Cramer; Linda J Titus; Shelley S Tworoger; Kathryn L Terry Journal: Int J Cancer Date: 2013-07-09 Impact factor: 7.396
Authors: Mary Anne Rossing; Kara L Cushing-Haugen; Kristine G Wicklund; Jennifer A Doherty; Noel S Weiss Journal: Cancer Causes Control Date: 2008-08-14 Impact factor: 2.506
Authors: M G M Braem; N C Onland-Moret; P A van den Brandt; R A Goldbohm; P H M Peeters; R F P M Kruitwagen; L J Schouten Journal: Am J Epidemiol Date: 2010-09-22 Impact factor: 4.897