| Literature DB >> 15862889 |
Yan Sun1, Jiajun Shi, Sizhong Zhang, Mouni Tang, Haiying Han, Yangbo Guo, Cui Ma, Xiehe Liu, Tao Li.
Abstract
In order to clarify the relationship of apolipoprotein CIII (APOC3) polymorphism and sporadic Alzheimer's disease (AD) in Chinese, 165 sporadic AD patients and 174 age-matched elderly individuals were genotyped for the APOC3 SstI and apolipoprotein E (APOE) HhaI polymorphisms. As the result, the APOC3 3017G allele was found to be associated with AD in APOE epsilon4 allele noncarriers (chi2=4.433, P=0.035), and the risk estimate of allele C versus G resulted in an OR of 1.56 (95% CI: 1.03-2.37), although in total no significant differences of allelic or genotypic frequencies between patients and controls were found. Assessment of interaction between APOE epsilon4 and APOC3 3017G status presented an adjusted odds ratio of 0.62 (95% CI: 0.37-1.03) with a borderline significant P-value (P=0.066). Therefore, we conclude that the rare APOC3 G allele may offer some protection against the development of sporadic AD in APOE epsilon4 noncarriers in Chinese.Entities:
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Year: 2005 PMID： 15862889 DOI： 10.1016/j.neulet.2005.01.038
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046