| Literature DB >> 15862539 |
Minoru Fujiki1, Hidenori Kobayashi, Susumu Uchida, Ryo Inoue, Keisuke Ishii.
Abstract
This study evaluated the potential effect of donepezil, which is known as an acetylcholinesterase inhibitor used for treatment of Alzheimer's disease, against cerebral infarction induced by permanent left middle cerebral artery (MCA) occlusion. Donepezil was given orally in various regimens, prior to MCA occlusion in rats. Pretreatment with a single oral dose of donepezil (12 mg/kg), 2 h before ischemia, significantly attenuated cerebral infarction volume (165.5 +/- 105.3 vs. 377.1 +/- 48.5 mm(3); P < 0.05). These neuroprotective effects were prevented by coinjection with mecamylamine, a nicotinic acetylcholine-receptor (nAChR) antagonist, indicating that protection was mediated by nAChR activation.Entities:
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Year: 2005 PMID： 15862539 DOI： 10.1016/j.brainres.2005.02.063
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252