| Literature DB >> 15862180 |
Sanjoy K Bhattacharya, Suresh P Annangudi, Robert G Salomon, Rachel W Kuchtey, Neal S Peachey, John W Crabb.
Abstract
Cochlin deposits were observed in the trabecular meshwork (TM) of 8-month-old glaucomatous DBA/2J mice, coincident with the reported onset of increased intraocular pressure and optic nerve damage. An age-dependent increase in cochlin was observed up to 10 months of age and was paralleled by a decrease in type II collagen. Similar expression patterns exist in the TM of humans with primary open-angle glaucoma. Cochlin deposits, absent in non-glaucomatous mouse and human TM, may disrupt the TM extracellular matrix and obstruct aqueous humor circulation. Studies of DBA/2J mice offer promise for understanding the role cochlin may play in glaucoma.Entities:
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Year: 2005 PMID： 15862180 DOI： 10.1016/j.exer.2005.01.028
Source DB: PubMed Journal: Exp Eye Res ISSN： 0014-4835 Impact factor: 3.467