Literature DB >> 15862166

RPE lipofuscin and its role in retinal pathobiology.

Janet R Sparrow1, Mike Boulton.   

Abstract

Emerging evidence indicates that the autofluorescent pigments that accumulate as lipofuscin in retinal pigment epithelial (RPE) cells may reach levels that contribute to a decline in cell function. Since recent findings with respect to the origin, composition and adverse effects of RPE lipofuscin have informed our view of this material, the goal of this article is to review our current understanding of these issues.

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Year:  2005        PMID： 15862166     DOI： 10.1016/j.exer.2005.01.007

Source DB:  PubMed          Journal:  Exp Eye Res        ISSN： 0014-4835            Impact factor:   3.467


  249 in total

1.  Quantitative measurements of autofluorescence with the scanning laser ophthalmoscope.

Authors:  François Delori; Jonathan P Greenberg; Russell L Woods; Jörg Fischer; Tobias Duncker; Janet Sparrow; R Theodore Smith
Journal:  Invest Ophthalmol Vis Sci       Date:  2011-12-09       Impact factor: 4.799

Review 2.  Roles for the ubiquitin-proteasome pathway in protein quality control and signaling in the retina: implications in the pathogenesis of age-related macular degeneration.

Authors:  Fu Shang; Allen Taylor
Journal:  Mol Aspects Med       Date:  2012-04-10

3.  Lutein and zeaxanthin supplementation reduces photooxidative damage and modulates the expression of inflammation-related genes in retinal pigment epithelial cells.

Authors:  Qingning Bian; Shasha Gao; Jilin Zhou; Jian Qin; Allen Taylor; Elizabeth J Johnson; Guangwen Tang; Janet R Sparrow; Dennis Gierhart; Fu Shang
Journal:  Free Radic Biol Med       Date:  2012-06-23       Impact factor: 7.376

4.  Interpretations of fundus autofluorescence from studies of the bisretinoids of the retina.

Authors:  Janet R Sparrow; Kee Dong Yoon; Yalin Wu; Kazunori Yamamoto
Journal:  Invest Ophthalmol Vis Sci       Date:  2010-09       Impact factor: 4.799

Review 5.  Advances in imaging of Stargardt disease.

Authors:  Y Chen; A Roorda; J L Duncan
Journal:  Adv Exp Med Biol       Date:  2010       Impact factor: 2.622

6.  ATP-binding cassette transporter ABCA4: molecular properties and role in vision and macular degeneration.

Authors:  Robert S Molday
Journal:  J Bioenerg Biomembr       Date:  2007-12       Impact factor: 2.945

Review 7.  The role of the photoreceptor ABC transporter ABCA4 in lipid transport and Stargardt macular degeneration.

Authors:  Robert S Molday; Ming Zhong; Faraz Quazi
Journal:  Biochim Biophys Acta       Date:  2009-02-20

Review 8.  Age-related macular degeneration: genetics and biology coming together.

Authors:  Lars G Fritsche; Robert N Fariss; Dwight Stambolian; Gonçalo R Abecasis; Christine A Curcio; Anand Swaroop
Journal:  Annu Rev Genomics Hum Genet       Date:  2014-04-16       Impact factor: 8.929

9.  The lipofuscin fluorophore A2E perturbs cholesterol metabolism in retinal pigment epithelial cells.

Authors:  Aparna Lakkaraju; Silvia C Finnemann; Enrique Rodriguez-Boulan
Journal:  Proc Natl Acad Sci U S A       Date:  2007-06-19       Impact factor: 11.205

10.  Sublethal photic stress and the motility of RPE phagosomes and melanosomes.

Authors:  Janice M Burke; Mariusz Zareba
Journal:  Invest Ophthalmol Vis Sci       Date:  2008-12-13       Impact factor: 4.799
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