BACKGROUND: We conducted a meta-analysis to re-evaluate the role of the dopamine D4 receptor gene 48-base-pair- repeat (DRD4) polymorphism in mood disorders. METHODS: DRD4 allele frequencies were compared between 917 patients with unipolar (UP) or bipolar affective disorder (BP) and 1164 control subjects from 12 samples, using the Cochrane Review Manager. RESULTS: An association was found between all mood disorder groups and DRD4.2. After correcting for multiple testing, the association between DRD4.2 and BP dropped to insignificance; however, the evidence of an association between the DRD4.2 allele and UP (p < .001) and the combined group (p < .001) remained. There was no evidence for heterogeneity or publication bias. CONCLUSIONS: These findings suggest that the DRD4.2 allele is a risk allele for depression symptomatology. Meta-analysis may be a valuable objective tool for a quantitative summary of evidence for association studies in psychiatric genetics.
BACKGROUND: We conducted a meta-analysis to re-evaluate the role of the dopamine D4 receptor gene 48-base-pair- repeat (DRD4) polymorphism in mood disorders. METHODS:DRD4 allele frequencies were compared between 917 patients with unipolar (UP) or bipolar affective disorder (BP) and 1164 control subjects from 12 samples, using the Cochrane Review Manager. RESULTS: An association was found between all mood disorder groups and DRD4.2. After correcting for multiple testing, the association between DRD4.2 and BP dropped to insignificance; however, the evidence of an association between the DRD4.2 allele and UP (p < .001) and the combined group (p < .001) remained. There was no evidence for heterogeneity or publication bias. CONCLUSIONS: These findings suggest that the DRD4.2 allele is a risk allele for depression symptomatology. Meta-analysis may be a valuable objective tool for a quantitative summary of evidence for association studies in psychiatric genetics.
Authors: Erin C Dunn; Ruth C Brown; Yael Dai; Jonathan Rosand; Nicole R Nugent; Ananda B Amstadter; Jordan W Smoller Journal: Harv Rev Psychiatry Date: 2015 Jan-Feb Impact factor: 3.732
Authors: Diana R Samek; Jennifer Bailey; Karl G Hill; Sylia Wilson; Susanne Lee; Margaret A Keyes; Marina Epstein; Andrew Smolen; Michael Miller; Ken C Winters; J David Hawkins; Richard F Catalano; William G Iacono; Matt McGue Journal: Behav Genet Date: 2016-07-21 Impact factor: 2.805
Authors: Sandra López-León; Wing Chi Choy; Yurii S Aulchenko; Stephan J Claes; Ben A Oostra; Johan P Mackenbach; Cornelia M van Duijn; A Cecile J W Janssens Journal: PLoS One Date: 2009-03-31 Impact factor: 3.240
Authors: Hannah Kuper; Amanda Nicholson; Mika Kivimaki; Amina Aitsi-Selmi; Gianpiero Cavalleri; John E Deanfield; Peter Heuschmann; Xavier Jouven; Sofia Malyutina; Bongani M Mayosi; Susanna Sans; Troels Thomsen; Jacqueline C M Witteman; Aroon D Hingorani; Debbie A Lawlor; Harry Hemingway Journal: BMJ Date: 2009-11-05