Literature DB >> 15858637

Alkylation of natural endoperoxide G3-factor. Synthesis and antimalarial activity studies.

Fadia Najjar1, Liliane Gorrichon, Michel Baltas, Christiane André-Barrès, Henri Vial.   

Abstract

Alkylation of the peroxyhemiketal function is described and all synthesised endoperoxides show good antimalarial activity. New rearrangement reactions in the presence of CsCO3, and preliminary results on Fe(II) chemical reduction of the O-O bond are presented.

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Year:  2005        PMID： 15858637     DOI： 10.1039/b503402g

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  5 in total

Review 1.  Rearrangements of organic peroxides and related processes.

Authors:  Ivan A Yaremenko; Vera A Vil'; Dmitry V Demchuk; Alexander O Terent'ev
Journal:  Beilstein J Org Chem       Date:  2016-08-03       Impact factor: 2.883

2.  Artemisinin directly targets malarial mitochondria through its specific mitochondrial activation.

Authors:  Juan Wang; Liying Huang; Jian Li; Qiangwang Fan; Yicheng Long; Ying Li; Bing Zhou
Journal:  PLoS One       Date:  2010-03-08       Impact factor: 3.240

Review 3.  Synthesis of five- and six-membered cyclic organic peroxides: Key transformations into peroxide ring-retaining products.

Authors:  Alexander O Terent'ev; Dmitry A Borisov; Vera A Vil'; Valery M Dembitsky
Journal:  Beilstein J Org Chem       Date:  2014-01-08       Impact factor: 2.883

4.  Stereoelectronic source of the anomalous stability of bis-peroxides.

Authors:  Gabriel Dos Passos Gomes; Vera Vil'; Alexander Terent'ev; Igor V Alabugin
Journal:  Chem Sci       Date:  2015-09-07       Impact factor: 9.825

Review 5.  Biological actions of artemisinin: insights from medicinal chemistry studies.

Authors:  Jian Li; Bing Zhou
Journal:  Molecules       Date:  2010-03-08       Impact factor: 4.411
  5 in total

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