| Literature DB >> 15857690 |
Shinsuke Hayashida1, Masashi Katsura, Fumiko Torigoe, Atsushi Tsujimura, Seitaro Ohkuma.
Abstract
We investigated the effect of chronic nicotine administration on high voltage-gated calcium channels (HVCCs) in the mouse cerebral cortex. The treatment significantly increased expression of alpha1C, alpha1D, alpha1F, and alpha2/delta1 subunits with no changes of beta4 subunit of L-type HVCCs. [(3)H]Diltiazem binding to the particulate fractions increased with increased Bmax value. These results indicate that chronic nicotine treatment up-regulates L-type HVCCs, which is due to increased expression of alpha1 and alpha2/delta1 subunits.Entities:
Mesh：
Substances：
Year: 2004 PMID： 15857690 DOI： 10.1016/j.molbrainres.2004.11.002
Source DB: PubMed Journal: Brain Res Mol Brain Res ISSN： 0169-328X