Sally H Vitali1, Adrienne G Randolph. 1. Department of Anesthesia and the Division of Critical Care Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.
Abstract
OBJECTIVE: To define methodological standards that would improve the quality and reproducibility of case-control genetic association studies in sepsis. DESIGN: Summary of the published standards. RESULTS: Twelve main criteria and measures for evaluation of those criteria were developed from a variety of reviews and editorials on the subject. CONCLUSIONS: Case-control candidate gene association studies represent an important tool for understanding the role that genes play in the pathogenesis of sepsis. It is important, however, to understand the limitations of these studies and the need for replication.
OBJECTIVE: To define methodological standards that would improve the quality and reproducibility of case-control genetic association studies in sepsis. DESIGN: Summary of the published standards. RESULTS: Twelve main criteria and measures for evaluation of those criteria were developed from a variety of reviews and editorials on the subject. CONCLUSIONS: Case-control candidate gene association studies represent an important tool for understanding the role that genes play in the pathogenesis of sepsis. It is important, however, to understand the limitations of these studies and the need for replication.
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Authors: Julian Little; Julian P T Higgins; John P A Ioannidis; David Moher; France Gagnon; Erik von Elm; Muin J Khoury; Barbara Cohen; George Davey-Smith; Jeremy Grimshaw; Paul Scheet; Marta Gwinn; Robin E Williamson; Guang Yong Zou; Kim Hutchings; Candice Y Johnson; Valerie Tait; Miriam Wiens; Jean Golding; Cornelia van Duijn; John McLaughlin; Andrew Paterson; George Wells; Isabel Fortier; Matthew Freedman; Maja Zecevic; Richard King; Claire Infante-Rivard; Alex Stewart; Nick Birkett Journal: PLoS Med Date: 2009-02-03 Impact factor: 11.069
Authors: Julian Little; Julian P T Higgins; John P A Ioannidis; David Moher; France Gagnon; Erik von Elm; Muin J Khoury; Barbara Cohen; George Davey-Smith; Jeremy Grimshaw; Paul Scheet; Marta Gwinn; Robin E Williamson; Guang Yong Zou; Kim Hutchings; Candice Y Johnson; Valerie Tait; Miriam Wiens; Jean Golding; Cornelia van Duijn; John McLaughlin; Andrew Paterson; George Wells; Isabel Fortier; Matthew Freedman; Maja Zecevic; Richard King; Claire Infante-Rivard; Alex Stewart; Nick Birkett Journal: Eur J Clin Invest Date: 2009-04 Impact factor: 4.686
Authors: Julian Little; Julian P T Higgins; John P A Ioannidis; David Moher; France Gagnon; Erik von Elm; Muin J Khoury; Barbara Cohen; George Davey-Smith; Jeremy Grimshaw; Paul Scheet; Marta Gwinn; Robin E Williamson; Guang Yong Zou; Kim Hutchings; Candice Y Johnson; Valerie Tait; Miriam Wiens; Jean Golding; Cornelia van Duijn; John McLaughlin; Andrew Paterson; George Wells; Isabel Fortier; Matthew Freedman; Maja Zecevic; Richard King; Claire Infante-Rivard; Alex Stewart; Nick Birkett Journal: Eur J Epidemiol Date: 2009-02-03 Impact factor: 8.082