Richard J Brilli1, Brahm Goldstein. 1. Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Abstract
OBJECTIVE: To review the past, present, and future definitions of sepsis and the systemic inflammatory response syndrome in children. METHODS: Review of the literature. RESULTS: The history and development of the adult-derived sepsis syndrome and its application to pediatric-specific sepsis definitions is provided. Initially, only adult definitions were applied to pediatric studies. Recently, pediatric-specific definitions have been published. The pediatric consensus conference-derived definitions for systemic inflammatory response syndrome, sepsis, severe sepsis, and septic shock are summarized, and their limitations are discussed. CONCLUSIONS: The potential value and inconsistencies of the current pediatric-specific sepsis definitions are discussed. Future direction of the definitions and their applications are presented.
OBJECTIVE: To review the past, present, and future definitions of sepsis and the systemic inflammatory response syndrome in children. METHODS: Review of the literature. RESULTS: The history and development of the adult-derived sepsis syndrome and its application to pediatric-specific sepsis definitions is provided. Initially, only adult definitions were applied to pediatric studies. Recently, pediatric-specific definitions have been published. The pediatric consensus conference-derived definitions for systemic inflammatory response syndrome, sepsis, severe sepsis, and septic shock are summarized, and their limitations are discussed. CONCLUSIONS: The potential value and inconsistencies of the current pediatric-specific sepsis definitions are discussed. Future direction of the definitions and their applications are presented.
Authors: Fauzia Paize; Richard Sarginson; Niten Makwana; Paul B Baines; Alistair P J Thomson; Ian Sinha; C Anthony Hart; Andrew Riordan; Kay C Hawkins; Enitan D Carrol; Christopher M Parry Journal: Intensive Care Med Date: 2012-03-08 Impact factor: 17.440
Authors: Andrea Wolfler; Paolo Silvani; Massimo Musicco; Massimo Antonelli; Ida Salvo Journal: Intensive Care Med Date: 2008-05-24 Impact factor: 17.440
Authors: Matthew O Wiens; Charles P Larson; Elias Kumbakumba; Niranjan Kissoon; J Mark Ansermino; Joel Singer; Hubert Wong; Andrew Ndamira; Jerome Kabakyenga; Peter Moschovis; Julius Kiwanuka Journal: Pediatr Crit Care Med Date: 2016-05 Impact factor: 3.624
Authors: Matthew O Wiens; Elias Kumbakumba; Niranjan Kissoon; J Mark Ansermino; Andrew Ndamira; Charles P Larson Journal: Clin Epidemiol Date: 2012-11-22 Impact factor: 4.790