Literature DB >> 15856066

Hypothalamic sensing of fatty acids.

Tony K T Lam1, Gary J Schwartz, Luciano Rossetti.   

Abstract

Selective regions of the brain, including the hypothalamus, are capable of gathering information on the body's nutritional status in order to implement appropriate behavioral and metabolic responses to changes in fuel availability. This review focuses on direct metabolic signaling within the hypothalamus. There is growing evidence supporting the idea that fatty acid metabolism within discrete hypothalamic regions can function as a sensor for nutrient availability that can integrate multiple nutritional and hormonal signals.

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Year:  2005        PMID: 15856066     DOI: 10.1038/nn1456

Source DB:  PubMed          Journal:  Nat Neurosci        ISSN: 1097-6256            Impact factor:   24.884


  150 in total

1.  A Fall in plasma free fatty acid (FFA) level activates the hypothalamic-pituitary-adrenal axis independent of plasma glucose: evidence for brain sensing of circulating FFA.

Authors:  Young Taek Oh; Ki-Sook Oh; Insug Kang; Jang H Youn
Journal:  Endocrinology       Date:  2012-06-05       Impact factor: 4.736

Review 2.  The regulation of food intake in mammalian hibernators: a review.

Authors:  Gregory L Florant; Jessica E Healy
Journal:  J Comp Physiol B       Date:  2011-11-12       Impact factor: 2.200

Review 3.  Obesity and adipokines: effects on sympathetic overactivity.

Authors:  Michael M Smith; Christopher T Minson
Journal:  J Physiol       Date:  2012-02-20       Impact factor: 5.182

Review 4.  Gustatory and reward brain circuits in the control of food intake.

Authors:  A J Oliveira-Maia; C D Roberts; S A Simon; M A L Nicolelis
Journal:  Adv Tech Stand Neurosurg       Date:  2011

Review 5.  Dietary Lipids Inform the Gut and Brain about Meal Arrival via CD36-Mediated Signal Transduction.

Authors:  Sinju Sundaresan; Nada A Abumrad
Journal:  J Nutr       Date:  2015-08-12       Impact factor: 4.798

Review 6.  Role of hypothalamic autophagy in the control of whole body energy balance.

Authors:  Min-Seon Kim; Wenying Quan; Myung-Shik Lee
Journal:  Rev Endocr Metab Disord       Date:  2013-12       Impact factor: 6.514

Review 7.  Genetic and epigenetic control of metabolic health.

Authors:  Robert Wolfgang Schwenk; Heike Vogel; Annette Schürmann
Journal:  Mol Metab       Date:  2013-09-25       Impact factor: 7.422

Review 8.  Neuroinflammatory basis of metabolic syndrome.

Authors:  Sudarshana Purkayastha; Dongsheng Cai
Journal:  Mol Metab       Date:  2013-10-05       Impact factor: 7.422

9.  Microglia dictate the impact of saturated fat consumption on hypothalamic inflammation and neuronal function.

Authors:  Martin Valdearcos; Megan M Robblee; Daniel I Benjamin; Daniel K Nomura; Allison W Xu; Suneil K Koliwad
Journal:  Cell Rep       Date:  2014-12-11       Impact factor: 9.423

10.  Glucokinase activity in the arcuate nucleus regulates glucose intake.

Authors:  Syed Hussain; Errol Richardson; Yue Ma; Christopher Holton; Ivan De Backer; Niki Buckley; Waljit Dhillo; Gavin Bewick; Shuai Zhang; David Carling; Steve Bloom; James Gardiner
Journal:  J Clin Invest       Date:  2014-12-08       Impact factor: 14.808

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