Literature DB >> 15855543

Differences in interactions between azole drugs related to modifications in the 14-alpha sterol demethylase gene (cyp51A) of Aspergillus fumigatus.

G Garcia-Effron1, E Mellado, A Gomez-Lopez, L Alcazar-Fuoli, M Cuenca-Estrella, Juan L Rodriguez-Tudela.   

Abstract

The combined activity of different azole drugs was investigated. Thirty-one Aspergillus fumigatus strains were tested, including two cyp51A(-) and one cyp51B(-) gene-knockout strain and azole-susceptible and -resistant strains with different resistance mechanisms. The combination of itraconazole and voriconazole was synergistic for all strains except for those with gene knockouts.

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Year:  2005        PMID： 15855543      PMCID： PMC1087680          DOI： 10.1128/AAC.49.5.2119-2121.2005

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  26 in total

1.  Interlaboratory evaluation of hematocytometer method of inoculum preparation for testing antifungal susceptibilities of filamentous fungi.

Authors:  J L Rodriguez-Tudela; Erja Chryssanthou; Evangelia Petrikkou; Juan Mosquera; David W Denning; Manuel Cuenca-Estrella
Journal:  J Clin Microbiol       Date:  2003-11       Impact factor: 5.948

Review 2.  Recent trends in the epidemiology of invasive mycoses.

Authors:  Thomas A Clark; Rana A Hajjeh
Journal:  Curr Opin Infect Dis       Date:  2002-12       Impact factor: 4.915

3.  Synergy, antagonism, and what the chequerboard puts between them.

Authors:  F C Odds
Journal:  J Antimicrob Chemother       Date:  2003-06-12       Impact factor: 5.790

4.  Potent synergistic in vitro interaction between nonantimicrobial membrane-active compounds and itraconazole against clinical isolates of Aspergillus fumigatus resistant to itraconazole.

Authors:  Javier Afeltra; Roxana G Vitale; Johan W Mouton; Paul E Verweij
Journal:  Antimicrob Agents Chemother       Date:  2004-04       Impact factor: 5.191

Review 5.  Combination antifungal therapy.

Authors:  Melissa D Johnson; Conan MacDougall; Luis Ostrosky-Zeichner; John R Perfect; John H Rex
Journal:  Antimicrob Agents Chemother       Date:  2004-03       Impact factor: 5.191

6.  Multiple resistance mechanisms among Aspergillus fumigatus mutants with high-level resistance to itraconazole.

Authors:  Adriana M Nascimento; Gustavo H Goldman; Steven Park; Salvatore A E Marras; Guillaume Delmas; Uma Oza; Karen Lolans; Michael N Dudley; Paul A Mann; David S Perlin
Journal:  Antimicrob Agents Chemother       Date:  2003-05       Impact factor: 5.191

7.  Differential activity of triazoles in two-drug combinations with the echinocandin caspofungin against Aspergillus fumigatus.

Authors:  Elias K Manavathu; George J Alangaden; Pranatharthi H Chandrasekar
Journal:  J Antimicrob Chemother       Date:  2003-04-25       Impact factor: 5.790

8.  A point mutation in the 14alpha-sterol demethylase gene cyp51A contributes to itraconazole resistance in Aspergillus fumigatus.

Authors:  T M Diaz-Guerra; E Mellado; M Cuenca-Estrella; J L Rodriguez-Tudela
Journal:  Antimicrob Agents Chemother       Date:  2003-03       Impact factor: 5.191

9.  In vitro activities of three licensed antifungal agents against spanish clinical isolates of Aspergillus spp.

Authors:  Alicia Gomez-Lopez; Guillermo Garcia-Effron; Emilia Mellado; Araceli Monzon; Juan L Rodriguez-Tudela; Manuel Cuenca-Estrella
Journal:  Antimicrob Agents Chemother       Date:  2003-10       Impact factor: 5.191

10.  Mutations in Aspergillus fumigatus resulting in reduced susceptibility to posaconazole appear to be restricted to a single amino acid in the cytochrome P450 14alpha-demethylase.

Authors:  Paul A Mann; Raulo M Parmegiani; Shui-Qing Wei; Cara A Mendrick; Xin Li; David Loebenberg; Beth DiDomenico; Roberta S Hare; Scott S Walker; Paul M McNicholas
Journal:  Antimicrob Agents Chemother       Date:  2003-02       Impact factor: 5.191
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  17 in total

1.  Molecular epidemiology of Aspergillus fumigatus isolates harboring the TR34/L98H azole resistance mechanism.

Authors:  Simone M T Camps; Antonius J M M Rijs; Corné H W Klaassen; Jacques F Meis; Céline M O'Gorman; Paul S Dyer; Willem J G Melchers; Paul E Verweij
Journal:  J Clin Microbiol       Date:  2012-06-06       Impact factor: 5.948

Review 2.  Rapid induction of multiple resistance mechanisms in Aspergillus fumigatus during azole therapy: a case study and review of the literature.

Authors:  Simone M T Camps; Jan W M van der Linden; Yi Li; Ed J Kuijper; Jaap T van Dissel; Paul E Verweij; Willem J G Melchers
Journal:  Antimicrob Agents Chemother       Date:  2011-10-17       Impact factor: 5.191

Review 3.  Stress, drugs, and evolution: the role of cellular signaling in fungal drug resistance.

Authors:  Leah E Cowen; William J Steinbach
Journal:  Eukaryot Cell       Date:  2008-03-28

4.  Aspergillus fumigatus Cyp51A and Cyp51B Proteins Are Compensatory in Function and Localize Differentially in Response to Antifungals and Cell Wall Inhibitors.

Authors:  Mark T Roundtree; Praveen R Juvvadi; E Keats Shwab; D Christopher Cole; William J Steinbach
Journal:  Antimicrob Agents Chemother       Date:  2020-09-21       Impact factor: 5.191

5.  Wild-type MIC distributions and epidemiological cutoff values for the triazoles and six Aspergillus spp. for the CLSI broth microdilution method (M38-A2 document).

Authors:  A Espinel-Ingroff; D J Diekema; A Fothergill; E Johnson; T Pelaez; M A Pfaller; M G Rinaldi; E Canton; J Turnidge
Journal:  J Clin Microbiol       Date:  2010-06-30       Impact factor: 5.948

6.  Effects of antifungal agents alone and in combination against Candida glabrata strains susceptible or resistant to fluconazole.

Authors:  Izabel Almeida Alves; Laíssa Arévalo Bandeira; Débora Alves Nunes Mario; Laura Bedin Denardi; Louise Vignoles Neves; Janio Morais Santurio; Sydney Hartz Alves
Journal:  Mycopathologia       Date:  2012-04-22       Impact factor: 2.574

Review 7.  Resistance to antifungals that target CYP51.

Authors:  Josie E Parker; Andrew G S Warrilow; Claire L Price; Jonathan G L Mullins; Diane E Kelly; Steven L Kelly
Journal:  J Chem Biol       Date:  2014-08-27

8.  In vitro survey of triazole cross-resistance among more than 700 clinical isolates of Aspergillus species.

Authors:  M A Pfaller; S A Messer; L Boyken; C Rice; S Tendolkar; R J Hollis; D J Diekema
Journal:  J Clin Microbiol       Date:  2008-06-18       Impact factor: 5.948

Review 9.  Molecular Tools for the Detection and Deduction of Azole Antifungal Drug Resistance Phenotypes in Aspergillus Species.

Authors:  Anna Dudakova; Birgit Spiess; Marut Tangwattanachuleeporn; Christoph Sasse; Dieter Buchheidt; Michael Weig; Uwe Groß; Oliver Bader
Journal:  Clin Microbiol Rev       Date:  2017-10       Impact factor: 26.132

10.  Wild-type MIC distribution and epidemiological cutoff values for Aspergillus fumigatus and three triazoles as determined by the Clinical and Laboratory Standards Institute broth microdilution methods.

Authors:  M A Pfaller; D J Diekema; M A Ghannoum; J H Rex; B D Alexander; D Andes; S D Brown; V Chaturvedi; A Espinel-Ingroff; C L Fowler; E M Johnson; C C Knapp; M R Motyl; L Ostrosky-Zeichner; D J Sheehan; T J Walsh
Journal:  J Clin Microbiol       Date:  2009-08-19       Impact factor: 5.948
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