| Literature DB >> 15854898 |
Abstract
The rate limiting step for actin filament polymerisation is nucleation, and two types of nucleator have been described: the Arp2/3 complex and the formins. A recent study has now identified in Spire a third class of actin nucleator. The four short WH2 repeats within Spire bind four consecutive actin monomers to form a novel single strand nucleus for 'barbed end' actin filament elongation.Entities:
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Year: 2005 PMID： 15854898 DOI： 10.1016/j.cub.2005.04.004
Source DB: PubMed Journal: Curr Biol ISSN： 0960-9822 Impact factor: 10.834