Literature DB >> 158538

An uptake of fluorescein isothiocyanate labeled neocarzinostatin into the cancer and normal cells.

S Sakamoto, H Maeda, J Ogata.   

Abstract

An uptake of fluorescein isothiocyanate labeled neocarzinostatin into normal and cancerous epithelial cells from bladder was investigated. Results showed that neocarzinostatin traversed the cell membrane into cytosol and nuclei, and it appeared to have a preferential cytotoxicity for the cancer cell.

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Year:  1979        PMID： 158538     DOI： 10.1007/bf01963309

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  10 in total

1.  Specific G2 block in HeLa-S3 cells by neocarzinostatin.

Authors:  T Ebina; K Otsuki; M Seto; N Ishida
Journal:  Eur J Cancer       Date:  1975-03       Impact factor: 9.162

2.  DNA strand scission by the antitumor protein neocarzinostatin.

Authors:  T A Beerman; I H Goldberg
Journal:  Biochem Biophys Res Commun       Date:  1974-08-19       Impact factor: 3.575

3.  Effect of neocarzinostatin on DNA synthesis in L1210 cells.

Authors:  H Sawada; K Tatsumi; M Sasada; S Shirakawa; T Nakamura
Journal:  Cancer Res       Date:  1974-12       Impact factor: 12.701

4.  Different drugs arrest cells at a number of distinct stages in G2.

Authors:  R A Tobey
Journal:  Nature       Date:  1975-03-20       Impact factor: 49.962

5.  Subcellular fate of protein antibiotic neocarzinostatin in culture of a lymphoid cell line from Burkitt's lymphoma.

Authors:  H Maeda; S Aikawa; A Yamashita
Journal:  Cancer Res       Date:  1975-03       Impact factor: 12.701

6.  Inhibition of surface immunoglobulin centeral capping of Daudi cells and cell spreading of HeLa-S3 cells by neocarzinostatin.

Authors:  T Ebina; M Satake; N Ishida
Journal:  Cancer Res       Date:  1977-12       Impact factor: 12.701

7.  In vitro inhibition of human leukemic cells (CCRF-CEM) by agarose-immobilized neocarzinostatin.

Authors:  H Lazarus; V Raso; T S Samy
Journal:  Cancer Res       Date:  1977-10       Impact factor: 12.701

8.  Gaps in DNA induced by neocarzinostatin bear 3'- and 5'-phosphoryl termini.

Authors:  L S Kappen; I H Goldberg
Journal:  Biochemistry       Date:  1978-02-21       Impact factor: 3.162

9.  The relationship between DNA strand-scission and DNA synthesis inhibition in HeLa cells treated with neocarzinostatin.

Authors:  T A Beerman; I H Goldberg
Journal:  Biochim Biophys Acta       Date:  1977-03-18

10.  Single-strand nicking of DNA in vitro by neocarzinostatin and its possible relationship to the mechanism of drug action.

Authors:  T A Beerman; R Poon; I H Goldberg
Journal:  Biochim Biophys Acta       Date:  1977-03-18
  10 in total
  2 in total

1.  Gene transcription analysis of Saccharomyces cerevisiae exposed to neocarzinostatin protein-chromophore complex reveals evidence of DNA damage, a potential mechanism of resistance, and consequences of prolonged exposure.

Authors:  S E Schaus; D Cavalieri; A G Myers
Journal:  Proc Natl Acad Sci U S A       Date:  2001-09-18       Impact factor: 11.205

2.  A pharmacokinetic simulation model for chemotherapy of brain tumor with an antitumor protein antibiotic, neocarzinostatin. Theoretical considerations behind a two-compartment model for continuous infusion via an internal carotid artery.

Authors:  H Maeda; Y Sano; J Takeshita; Z Iwai; H Kosaka; T Marubayashi; Y Matsukado
Journal:  Cancer Chemother Pharmacol       Date:  1981       Impact factor: 3.333
  2 in total

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