Literature DB >> 158537

Pimozide and p-chlorophenylalanine blockade in DL-amphetamine and pargyline-treated rats held at two environmental temperatures.

B A Panaretto.   

Abstract

In rats, treated with DL-amphetamine + monoamine oxidase inhibitor, and held at an ambient temperature of 28.5 degrees C, hyperthermia was completely eliminated by treatment with pimozide + p-chlorophenyl-alanine. The same drugs markedly reduced the hypothermic effects in rats treated similarly at 4 degrees C. Results implied that serotoninergic and dopaminergic neurones were involved in the thermoregulatory effects of amphetamine.

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Year:  1979        PMID： 158537     DOI： 10.1007/bf01963303

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  9 in total

1.  Release of brain dopamine as the probable mechanism for the hypothermic effect of D-amphetamine.

Authors:  S Yehuda; R J Wurtman
Journal:  Nature       Date:  1972-12-22       Impact factor: 49.962

2.  Antagonism of (+)-amphetamine-induced hyperthermia in rats by pimozide.

Authors:  C Matsumoto; W Griffin
Journal:  J Pharm Pharmacol       Date:  1971-09       Impact factor: 3.765

3.  Inhibition of (+)-amphetamine hyperthermia by blockade of dopamine receptors in rabbits.

Authors:  H F Hill; A Horita
Journal:  J Pharm Pharmacol       Date:  1971-09       Impact factor: 3.765

4.  Role of brain monoamines in the fatal hyperthermia induced by pethidine or imipramine in rabbits pretreated with a monoamine oxidase inhibitor.

Authors:  S N Gong; K J Rogers
Journal:  Br J Pharmacol       Date:  1973-05       Impact factor: 8.739

5.  The effects of D-amphetamine and related drugs on colonic temperatures of rats kept at various ambient temperatures.

Authors:  S Yehuda; R J Wurtman
Journal:  Life Sci I       Date:  1972-09-15

6.  p-Chlorophenylalanine: a specific depletor of brain serotonin.

Authors:  B K Koe; A Weissman
Journal:  J Pharmacol Exp Ther       Date:  1966-12       Impact factor: 4.030

7.  Receptor activity and turnover of dopamine and noradrenaline after neuroleptics.

Authors:  N E Andén; S G Butcher; H Corrodi; K Fuxe; U Ungerstedt
Journal:  Eur J Pharmacol       Date:  1970       Impact factor: 4.432

8.  Turnover rate of brain 5-hydroxytryptamine increased by D-amphetamine.

Authors:  W D Reid
Journal:  Br J Pharmacol       Date:  1970-11       Impact factor: 8.739

9.  Evidence for involvement of 5-hydroxytryptamine in the actions of amphetamine.

Authors:  G R Breese; B R Cooper; R A Mueller
Journal:  Br J Pharmacol       Date:  1974-10       Impact factor: 8.739
  9 in total

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