Literature DB >> 15852490

Siberian ginseng reduces infarct volume in transient focal cerebral ischaemia in Sprague-Dawley rats.

Yungmin Bu1, Zhen Hua Jin, Sun Young Park, Sunkyung Baek, Sungju Rho, Nina Ha, Seong Kyu Park, Hocheol Kim.   

Abstract

Siberian ginseng, the root and stem bark of Acanthopanax senticosus Harms, has been used as a tonic and adaptogen to strengthen qi in traditional Korean medicine. The neuroprotective effects of water extracts of A. senticosus (ASW) were investigated in transient middle cerebral artery occlusion (MCAo, 90 min occlusion, 24 h reperfusion) of Sprague-Dawley rats. The infarct volume was significantly reduced by 36.6% after the peritoneal injection of ASW (100 mg[sol ]kg) compared with the control. In the immunohistochemical study, ASW markedly inhibited both cyclooxygenase-2 and OX-42 expressions in the penumbral region at 24 h after MCAo. These results suggest that A. senticosus has a neuroprotective effect by inhibiting inflammation and microglial activation in brain ischaemia. Copyright 2005 John Wiley & Sons, Ltd.

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Year:  2005        PMID： 15852490     DOI： 10.1002/ptr.1649

Source DB:  PubMed          Journal:  Phytother Res        ISSN： 0951-418X            Impact factor:   5.878


  7 in total

1.  Inhibition of TLR ligand- and interferon gamma-induced murine microglial activation by Panax notoginseng.

Authors:  Celine A Beamer; David M Shepherd
Journal:  J Neuroimmune Pharmacol       Date:  2011-12-21       Impact factor: 4.147

2.  Synergy and Antagonism of Active Constituents of ADAPT-232 on Transcriptional Level of Metabolic Regulation of Isolated Neuroglial Cells.

Authors:  Alexander Panossian; Rebecca Hamm; Onat Kadioglu; Georg Wikman; Thomas Efferth
Journal:  Front Neurosci       Date:  2013-02-20       Impact factor: 4.677

3.  Effect of combination therapy with sodium ozagrel and panax ginseng on transient cerebral ischemia model in rats.

Authors:  Sang In Park; Dong-Kyu Jang; Young-Min Han; Yun-Young Sunwoo; Moon-Seo Park; Yong-An Chung; Lee-So Maeng; Ruth Im; Min-Wook Kim; Sin-Soo Jeun; Kyung-Sool Jang
Journal:  J Biomed Biotechnol       Date:  2011-01-03

Review 4.  Effects of Adaptogens on the Central Nervous System and the Molecular Mechanisms Associated with Their Stress-Protective Activity.

Authors:  Alexander Panossian; Georg Wikman
Journal:  Pharmaceuticals (Basel)       Date:  2010-01-19

5.  Eleutheroside E, An Active Component of Eleutherococcus senticosus, Ameliorates Insulin Resistance in Type 2 Diabetic db/db Mice.

Authors:  Jiyun Ahn; Min Young Um; Hyunjung Lee; Chang Hwa Jung; Seok Hyun Heo; Tae Youl Ha
Journal:  Evid Based Complement Alternat Med       Date:  2013-04-10       Impact factor: 2.629

6.  Reduction of urate crystal-induced inflammation by root extracts from traditional oriental medicinal plants: elevation of prostaglandin D2 levels.

Authors:  Sung Mun Jung; H Ralph Schumacher; Hocheol Kim; Miyeon Kim; Seoung Hoon Lee; Frank Pessler
Journal:  Arthritis Res Ther       Date:  2007       Impact factor: 5.156

7.  Combination of syringaresinol-di-O-β-D-glucoside and chlorogenic acid shows behavioral pharmacological anxiolytic activity and activation of hippocampal BDNF-TrkB signaling.

Authors:  Shouhei Miyazaki; Yoshio Fujita; Hirotaka Oikawa; Hideo Takekoshi; Hideaki Soya; Masato Ogata; Takahiko Fujikawa
Journal:  Sci Rep       Date:  2020-10-23       Impact factor: 4.379
  7 in total

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