Literature DB >> 15852021

Target accessibility dictates the potency of human RISC.

Kirk M Brown1, Chia-Ying Chu, Tariq M Rana.   

Abstract

In this report, we examined the effect of increased target site access on activated human RNA-induced silencing complex (RISC(*)) catalysis. Kinetic studies revealed that siRNA-programmed RISC(*) cleaved target RNA with higher efficiencies when target site access was increased. These results provide evidence that target site access is linked to RISC(*) catalysis.

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Year:  2005        PMID： 15852021     DOI： 10.1038/nsmb931

Source DB:  PubMed          Journal:  Nat Struct Mol Biol        ISSN： 1545-9985            Impact factor:   15.369


  57 in total

Review 1.  Action and reaction: the biological response to siRNA and its delivery vehicles.

Authors:  Rosemary L Kanasty; Kathryn A Whitehead; Arturo J Vegas; Daniel G Anderson
Journal:  Mol Ther       Date:  2012-01-17       Impact factor: 11.454

2.  HIV-l and the microRNA-guided silencing pathway: an intricate and multifaceted encounter.

Authors:  Patrick Provost; Corinne Barat; Isabelle Plante; Michel J Tremblay
Journal:  Virus Res       Date:  2006-08-04       Impact factor: 3.303

3.  Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing.

Authors:  Aimee L Jackson; Julja Burchard; Devin Leake; Angela Reynolds; Janell Schelter; Jie Guo; Jason M Johnson; Lee Lim; Jon Karpilow; Kim Nichols; William Marshall; Anastasia Khvorova; Peter S Linsley
Journal:  RNA       Date:  2006-05-08       Impact factor: 4.942

4.  Computational estimation and experimental verification of off-target silencing during posttranscriptional gene silencing in plants.

Authors:  Ping Xu; Yuanji Zhang; Li Kang; Marilyn J Roossinck; Kirankumar S Mysore
Journal:  Plant Physiol       Date:  2006-08-18       Impact factor: 8.340

5.  Potent RNAi by short RNA triggers.

Authors:  Chia-Ying Chu; Tariq M Rana
Journal:  RNA       Date:  2008-07-24       Impact factor: 4.942

Review 6.  Viral and cellular microRNAs as determinants of viral pathogenesis and immunity.

Authors:  Eva Gottwein; Bryan R Cullen
Journal:  Cell Host Microbe       Date:  2008-06-12       Impact factor: 21.023

Review 7.  Emergence of a complex relationship between HIV-1 and the microRNA pathway.

Authors:  Dominique L Ouellet; Isabelle Plante; Corinne Barat; Michel J Tremblay; Patrick Provost
Journal:  Methods Mol Biol       Date:  2009

8.  Improved asymmetry prediction for short interfering RNAs.

Authors:  Amanda P Malefyt; Ming Wu; Daniel B Vocelle; Sean J Kappes; Stephen D Lindeman; Christina Chan; S Patrick Walton
Journal:  FEBS J       Date:  2014-01       Impact factor: 5.542

9.  Evolutionary emergence of microRNAs in human embryonic stem cells.

Authors:  Hong Cao; Chao-shun Yang; Tariq M Rana
Journal:  PLoS One       Date:  2008-07-30       Impact factor: 3.240

10.  RNAi revised--target mRNA-dependent enhancement of gene silencing.

Authors:  Simon Dornseifer; Sarah Willkomm; Rosel Kretschmer-Kazemi Far; Janine Liebschwager; Foteini Beltsiou; Kirsten Frank; Sandra D Laufer; Thomas Martinetz; Georg Sczakiel; Jens Christian Claussen; Tobias Restle
Journal:  Nucleic Acids Res       Date:  2015-11-17       Impact factor: 16.971
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