Literature DB >> 158519

Serotonin as a differentiation signal in early neurogenesis.

J M Lauder, H Krebs.   

Abstract

The hypothesis that serotonin (5-HT) influences the onset of differentiation (cessation of division) of prospective 5-HT target neurons during embryogenesis was tested by administering the 5-HT depleting drug p-chlorophenylalanine (pCPA) to pregnant rats and dating the time of last cell division for fetal neurons using long survival 3H-thymidine autoradiography. PCPA specifically retarded the onset of neuronal differentiation in brain regions known to contain 5-HT terminals or to have a high 5-HT content in the adult (5-HT target cells). Conversely, the 'stress' of daily vehicle injections accelerated onset of differentiation in these regions, possibly due to stimulation of 5-HT synthesis by glucocorticoids. These data support the model of 5-HT as a humoral signal for the differentiation of cells later recognized by 5-HT neurons as appropriate targets for synaptogenesis.

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Year:  1978        PMID： 158519     DOI： 10.1159/000112549

Source DB:  PubMed          Journal:  Dev Neurosci        ISSN： 0378-5866            Impact factor:   2.984


  67 in total

Review 1.  Monoamine oxidases in development.

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2.  Platelet serotonin, a possible marker for familial autism.

Authors:  J Piven; G C Tsai; E Nehme; J T Coyle; G A Chase; S E Folstein
Journal:  J Autism Dev Disord       Date:  1991-03

Review 3.  Fetal, maternal, and placental sources of serotonin and new implications for developmental programming of the brain.

Authors:  A Bonnin; P Levitt
Journal:  Neuroscience       Date:  2011-10-08       Impact factor: 3.590

4.  Serotonin promotes the differentiation of glutamate neurons in organotypic slice cultures of the developing cerebral cortex.

Authors:  A A Lavdas; M E Blue; J Lincoln; J G Parnavelas
Journal:  J Neurosci       Date:  1997-10-15       Impact factor: 6.167

Review 5.  Understanding behavioral effects of early life stress using the reactive scope and allostatic load models.

Authors:  Brittany R Howell; Mar M Sanchez
Journal:  Dev Psychopathol       Date:  2011-11

Review 6.  Developmental trajectories during adolescence in males and females: a cross-species understanding of underlying brain changes.

Authors:  Heather C Brenhouse; Susan L Andersen
Journal:  Neurosci Biobehav Rev       Date:  2011-05-12       Impact factor: 8.989

Review 7.  Modulation of in vivo neuronal sprouting by serotonin in the adult CNS of the snail.

Authors:  M W Baker; R P Croll
Journal:  Cell Mol Neurobiol       Date:  1996-10       Impact factor: 5.046

8.  Early ontogeny of serotonin-immunoreactivity in the sheep brain. An immunohistochemical study.

Authors:  Y Tillet
Journal:  Anat Embryol (Berl)       Date:  1988

9.  Short- and long-term effects of (+)-methamphetamine and (+/-)-3,4-methylenedioxymethamphetamine on monoamine and corticosterone levels in the neonatal rat following multiple days of treatment.

Authors:  Tori L Schaefer; Matthew R Skelton; Nicole R Herring; Gary A Gudelsky; Charles V Vorhees; Michael T Williams
Journal:  J Neurochem       Date:  2007-11-06       Impact factor: 5.372

10.  The effects of serotonin on the differentiation of neurons producing vasoactive intestinal polypeptide in the suprachiasmatic nucleus of the rat.

Authors:  V V Mirochnik; M V Ugryumov; O Bosler; A Calas
Journal:  Neurosci Behav Physiol       Date:  2003-09
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