Literature DB >> 1585181

DNA hydrolyzing autoantibodies.

A M Shuster1, G V Gololobov, O A Kvashuk, A E Bogomolova, I V Smirnov, A G Gabibov.   

Abstract

A DNA-nicking activity was detected in the sera of patients with various autoimmune pathologies and was shown to be a property of autoantibodies. The DNA hydrolyzing activity, which was purified by affinity and high-performance liquid chromatography, corresponded in size to immunoglobulin M (IgM) and IgG and had a positive response to antibodies to human IgG. The DNA hydrolyzing autoantibodies were stable to acid shock and yielded a DNA degradation pattern that was different from that of deoxyribonuclease (DNase) I and blood DNase.

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Year:  1992        PMID： 1585181     DOI： 10.1126/science.1585181

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  76 in total

1.  Some Bence-Jones proteins enter cultured renal tubular cells, reach nuclei and induce cell death.

Authors:  K Matsuura; S Ikoma; M Watanabe; A Togawa; H Sinohara
Journal:  Immunology       Date:  1999-12       Impact factor: 7.397

2.  Natural antibody catalytic activities in mice with autoimmune disorders.

Authors:  N A Ponomarenko; E S Aleksandrova; I I Vorobiev; O M Durova; A V Kozyr; A V Kolesnikov; G B Telegin; A R Kalinina; S V Suchkov; A G Gabibov
Journal:  Dokl Biochem       Date:  2000 Nov-Dec

3.  DNA binding mode of the Fab fragment of a monoclonal antibody specific for cyclobutane pyrimidine dimer.

Authors:  T Torizawa; N Yamamoto; T Suzuki; K Nobuoka; Y Komatsu; H Morioka; O Nikaido; E Ohtsuka; K Kato; I Shimada
Journal:  Nucleic Acids Res       Date:  2000-02-15       Impact factor: 16.971

4.  Enzyme mimicry by the antiidiotypic antibody approach.

Authors:  A V Kolesnikov; A V Kozyr; E S Alexandrova; F Koralewski; A V Demin; M I Titov; B Avalle; A Tramontano; S Paul; D Thomas; A G Gabibov; A Friboulet
Journal:  Proc Natl Acad Sci U S A       Date:  2000-12-05       Impact factor: 11.205

5.  Caspase-dependent cytotoxicity of anti-DNA autoantibodies.

Authors:  L P Sashchenko; S V Khaidukov; A V Kozyr; T I Luk'yanova; A G Gabibov; S V Suchkov; T V Bobik; Z S Alekberova; N V Gnuchev
Journal:  Dokl Biochem Biophys       Date:  2001 Sep-Oct       Impact factor: 0.788

6.  Study of the dynamics of supercoiled DNA.

Authors:  E A Yakubovskaya; M A Lukin; A V Reshetnyak; A G Gabibov; M I Monastyrskii
Journal:  Dokl Biochem Biophys       Date:  2003 May-Jun       Impact factor: 0.788

7.  On the catalytic activity of autoantibodies in multiple sclerosis.

Authors:  N A Ponomarenko; O M Durova; I I Vorob'ev; S V Suchkov; A G Gabibov
Journal:  Dokl Biochem Biophys       Date:  2004 Mar-Apr       Impact factor: 0.788

Review 8.  Antibodies as defensive enzymes.

Authors:  Sudhir Paul; Yasuhiro Nishiyama; Stephanie Planque; Sangeeta Karle; Hiroaki Taguchi; Carl Hanson; Marc E Weksler
Journal:  Springer Semin Immunopathol       Date:  2005-01-05

9.  High levels of catalytic antibodies correlate with favorable outcome in sepsis.

Authors:  Sébastien Lacroix-Desmazes; Jagadeesh Bayry; Srini V Kaveri; David Hayon-Sonsino; Nithyananda Thorenoor; Julien Charpentier; Charles-Edouard Luyt; Jean-Paul Mira; Valakunja Nagaraja; Michel D Kazatchkine; Jean-François Dhainaut; Vincent O Mallet
Journal:  Proc Natl Acad Sci U S A       Date:  2005-03-02       Impact factor: 11.205

Review 10.  Catalytic antibodies in healthy humans and patients with autoimmune and viral diseases.

Authors:  G A Nevinsky; Valentina N Buneva
Journal:  J Cell Mol Med       Date:  2003 Jul-Sep       Impact factor: 5.310
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