| Literature DB >> 15851023 |
Koichi Akashi1, David Traver, Leonard I Zon.
Abstract
In this issue of Cell, a study by Adolfsson and coworkers (Adolfsson et al., 2005) provides insight into the early lineage commitment events of multipotent hematopoietic stem cells (HSCs). These studies demonstrate the importance of the Flt3 receptor tyrosine kinase as the earliest marker of hematopoietic cell fate commitment in that erythrocyte and megakaryocyte potentials are lost first as HSCs differentiate to lymphocyte progenitors.Entities:
Mesh：
Year: 2005 PMID： 15851023 DOI： 10.1016/j.cell.2005.04.005
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582