OBJECTIVE: Prevention of arterial thrombotic diseases has high priority in developed countries. Because people who eat inappropriate food are prone to thrombotic events, regular intake of an antithrombotic diet may offer a convenient and effective way of prevention. The aim of the present study was to find herbs that have antithrombotic effects. METHODS: Herbs were crushed and centrifuged and the juice obtained was filtered. The effect of filtrate on platelet-rich thrombus formation was assessed by a shear-induced in vitro platelet function test (hemostatometry). Filtrates showing significant antithrombotic activity were further assessed by using a laser-induced in vivo thrombosis test in mice. The effect of orally administered herb filtrates on flow-mediated vasodilation was also measured. RESULTS: Common thyme and rosemary showed significant antithrombotic activity in vitro and in vivo. Neither herb affected flow-mediated vasodilation. CONCLUSION: Some herbs possess antithrombotic effects in experimental models of thrombosis. The mechanism of the antithrombotic effect of common thyme and rosemary may involve a direct inhibitory effect on platelets.
OBJECTIVE: Prevention of arterial thrombotic diseases has high priority in developed countries. Because people who eat inappropriate food are prone to thrombotic events, regular intake of an antithrombotic diet may offer a convenient and effective way of prevention. The aim of the present study was to find herbs that have antithrombotic effects. METHODS: Herbs were crushed and centrifuged and the juice obtained was filtered. The effect of filtrate on platelet-rich thrombus formation was assessed by a shear-induced in vitro platelet function test (hemostatometry). Filtrates showing significant antithrombotic activity were further assessed by using a laser-induced in vivo thrombosis test in mice. The effect of orally administered herb filtrates on flow-mediated vasodilation was also measured. RESULTS: Common thyme and rosemary showed significant antithrombotic activity in vitro and in vivo. Neither herb affected flow-mediated vasodilation. CONCLUSION: Some herbs possess antithrombotic effects in experimental models of thrombosis. The mechanism of the antithrombotic effect of common thyme and rosemary may involve a direct inhibitory effect on platelets.
Authors: Isabel Borrás-Linares; Zorica Stojanović; Rosa Quirantes-Piné; David Arráez-Román; Jaroslava Švarc-Gajić; Alberto Fernández-Gutiérrez; Antonio Segura-Carretero Journal: Int J Mol Sci Date: 2014-11-10 Impact factor: 5.923
Authors: D C Zamberlan; G P Amaral; L P Arantes; M L Machado; C R Mizdal; M M A Campos; F A A Soares Journal: Braz J Med Biol Res Date: 2016-08-01 Impact factor: 2.590
Authors: Shahenur Alam Sakib; Abu Montakim Tareq; Ameerul Islam; Ahmed Rakib; Mohammad Nazmul Islam; Mohammad Arafat Uddin; Md Masudur Rahman; Veronique Seidel; Talha Bin Emran Journal: Plants (Basel) Date: 2021-05-27
Authors: M Atiar Rahman; Rabeya Sultana; Talha Bin Emran; M Saiful Islam; M Ashiqur Rahman; Joti Sankhar Chakma; Harun-ur Rashid; Chowdhury Mohammad Monirul Hasan Journal: BMC Complement Altern Med Date: 2013-01-30 Impact factor: 3.659