OBJECTIVE: Selenoprotein-P is a selenium-rich serum protein that carries more than 50% of serum selenium. We evaluated changes in serum selenoprotein-P levels in patients with inflammatory bowel disease. METHODS: Serum selenoprotein-P levels were measured by enzyme-linked immunosorbent assay. Twenty healthy individuals (controls), 34 patients with ulcerative colitis, and 37 patients with Crohn's disease (CD) were studied. RESULTS: A highly significant correlation was found between the serum selenium and selenoprotein-P levels. There was no significant difference in serum selenoprotein-P levels between healthy controls (average 3.4+/-0.8 microg/mL, n=20) and patients with ulcerative colitis (3.0+/-1.0 microg/mL, n=34). Serum selenoprotein-P levels were significantly lower in patients with CD (average 1.8+/-0.5 microg/mL, n=37). Serum selenoprotein-P levels were significantly lower in the elemental diet group of patients who had CD (average 1.4+/-0.4 microg/mL, n=17) than in the non-elemental diet group of patients who had CD (average 2.1+/-0.3 microg/mL, n=20). CONCLUSION: We found that the serum selenoprotein-P level is decreased in patients with CD. It may be a useful marker to monitor the systemic selenium status in various disorders.
OBJECTIVE:Selenoprotein-P is a selenium-rich serum protein that carries more than 50% of serum selenium. We evaluated changes in serum selenoprotein-P levels in patients with inflammatory bowel disease. METHODS: Serum selenoprotein-P levels were measured by enzyme-linked immunosorbent assay. Twenty healthy individuals (controls), 34 patients with ulcerative colitis, and 37 patients with Crohn's disease (CD) were studied. RESULTS: A highly significant correlation was found between the serum selenium and selenoprotein-P levels. There was no significant difference in serum selenoprotein-P levels between healthy controls (average 3.4+/-0.8 microg/mL, n=20) and patients with ulcerative colitis (3.0+/-1.0 microg/mL, n=34). Serum selenoprotein-P levels were significantly lower in patients with CD (average 1.8+/-0.5 microg/mL, n=37). Serum selenoprotein-P levels were significantly lower in the elemental diet group of patients who had CD (average 1.4+/-0.4 microg/mL, n=17) than in the non-elemental diet group of patients who had CD (average 2.1+/-0.3 microg/mL, n=20). CONCLUSION: We found that the serum selenoprotein-P level is decreased in patients with CD. It may be a useful marker to monitor the systemic selenium status in various disorders.
Authors: Naveen Kaushal; Avinash K Kudva; Andrew D Patterson; Christopher Chiaro; Mary J Kennett; Dhimant Desai; Shantu Amin; Bradley A Carlson; Margherita T Cantorna; K Sandeep Prabhu Journal: J Immunol Date: 2014-09-03 Impact factor: 5.422
Authors: Caitlyn W Barrett; Vishruth K Reddy; Sarah P Short; Amy K Motley; Mary K Lintel; Amber M Bradley; Tanner Freeman; Jefferson Vallance; Wei Ning; Bobak Parang; Shenika V Poindexter; Barbara Fingleton; Xi Chen; Mary K Washington; Keith T Wilson; Noah F Shroyer; Kristina E Hill; Raymond F Burk; Christopher S Williams Journal: J Clin Invest Date: 2015-06-08 Impact factor: 14.808
Authors: Sarah P Short; Jennifer M Pilat; Caitlyn W Barrett; Vishruth K Reddy; Yael Haberman; Jared R Hendren; Benjamin J Marsh; Cody E Keating; Amy K Motley; Kristina E Hill; Anne E Zemper; M Kay Washington; Chanjuan Shi; Xi Chen; Keith T Wilson; Jeffrey S Hyams; Lee A Denson; Raymond F Burk; Michael J Rosen; Christopher S Williams Journal: Gastroenterology Date: 2021-01-01 Impact factor: 22.682