| Literature DB >> 15850673 |
Simona Francisconi1, Mara Codenotti, Giulia Ferrari-Toninelli, Daniela Uberti, Maurizio Memo.
Abstract
The mismatch repair system (MMR) is an important member of the DNA checkpoint, that includes a number of protein deputed to control genomic stability through cell cycle arrest, DNA repair, and apoptosis. Here we summarize some recent data from our and other groups underlining the contribution to neurodegeneration of MSH2, perhaps the most relevant component of the MMR system. These data suggest that this protein participates not only in the cancer prevention machinery for the body but also in neurodegenerative processes.Entities:
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Year: 2005 PMID： 15850673 DOI： 10.1016/j.brainresrev.2004.12.023
Source DB: PubMed Journal: Brain Res Brain Res Rev