Literature DB >> 15850474

Detection of multiple hepatitis C virus genotypes in a cohort of injecting drug users.

S Bowden1, R McCaw, P A White, N Crofts, C K Aitken.   

Abstract

Multiple genotypes of the hepatitis C virus (HCV) were detected in five of 138 HCV RNA positive injecting drug users (IDUs) recruited in Melbourne, Australia. Two were detected by combined LiPA and core and NS5a region sequencing, and three more (selected for testing due to their high-risk behaviour) by heteroduplex mobility analysis. We conclude that the true prevalence of mixed infection in IDUs is undoubtedly higher than the 3.6% (five of 138) we observed, and is underestimated by LiPA, the most common method of genotyping. As responsiveness to HCV treatment varies significantly with genotype, a high prevalence of mixed HCV infections in IDUs must diminish overall treatment efficacy and lessen our ability to reduce the burden of HCV-related disease.

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Year:  2005        PMID： 15850474     DOI： 10.1111/j.1365-2893.2005.00592.x

Source DB:  PubMed          Journal:  J Viral Hepat        ISSN： 1352-0504            Impact factor:   3.728


  7 in total

1.  Access to sterile injecting equipment is more important than awareness of HCV status for injection risk behaviors among drug users.

Authors:  Joseph Cox; Carole Morissette; Prithwish De; Claude Tremblay; Robert Allard; Lisa Graves; Randolph Stephenson; Elise Roy
Journal:  Subst Use Misuse       Date:  2009       Impact factor: 2.164

Review 2.  Mixed HCV infection and reinfection in people who inject drugs--impact on therapy.

Authors:  Evan B Cunningham; Tanya L Applegate; Andrew R Lloyd; Gregory J Dore; Jason Grebely
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2015-03-17       Impact factor: 46.802

3.  Origin and evolution of the unique hepatitis C virus circulating recombinant form 2k/1b.

Authors:  Jayna Raghwani; Xiomara V Thomas; Sylvie M Koekkoek; Janke Schinkel; Richard Molenkamp; Thijs J van de Laar; Yutaka Takebe; Yasuhito Tanaka; Masashi Mizokami; Andrew Rambaut; Oliver G Pybus
Journal:  J Virol       Date:  2011-11-23       Impact factor: 5.103

4.  Dynamic coinfection with multiple viral subtypes in acute hepatitis C.

Authors:  Jennifer A Smith; Judith H Aberle; Vicki M Fleming; Peter Ferenci; Emma C Thomson; Peter Karayiannis; Angela R McLean; Heidemarie Holzmann; Paul Klenerman
Journal:  J Infect Dis       Date:  2010-11-10       Impact factor: 5.226

Review 5.  Controversies in and challenges to our understanding of hepatitis C.

Authors:  Robert G Batey
Journal:  World J Gastroenterol       Date:  2007-08-21       Impact factor: 5.742

6.  A reliable multiplex genotyping assay for HCV using a suspension bead array.

Authors:  Yi-Chen Yang; Der-Yuan Wang; Hwei-Fang Cheng; Eric Y Chuang; Mong-Hsun Tsai
Journal:  Microb Biotechnol       Date:  2014-07-10       Impact factor: 5.813

7.  Infection with multiple hepatitis C virus genotypes detected using commercial tests should be confirmed using next generation sequencing.

Authors:  Belén Fernández-Caso; Jose Ángel Fernández-Caballero; Natalia Chueca; Eukene Rojo; Adolfo de Salazar; Luisa García Buey; Laura Cardeñoso; Federico García
Journal:  Sci Rep       Date:  2019-06-25       Impact factor: 4.379
  7 in total

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