| Literature DB >> 15849869 |
Keizo Yamaguchi1, Akira Ohno, Fusako Kashitani, Morihiro Iwata, Makoto Kanda, Yoshiko Tsujio, Norihiko Shimoyama, Hidetoshi Okujima, Minoru Ito, Hideaki Kawaguchi, Hitoshi Chiba, Koji Akizawa, Yosei Katayama, Kumiko Sugimoto, Hiromi Tashiro, Mitsuomi Kaimori, Akira Suwabe, Ritsuko Obata, Tatsuro Sugiyama, Shunkoh Toyoshima, Jun Kato, Mitsuo Kaku, Keiji Kanemitsu, Hiroyuki Kunishima, Jun Okada, Yoko Tazawa, Jun Igari, Toyoko Oguri, Kiyoaki Watanabe, Yoshio Kobayashi, Hiroshi Uchida, Kyoichi Totsuka, Shinichiro Kon, Katsuji Nakamura, Keiko Matsuda, Izumi Hayashi, Joji Shiotani, Joji Shiotani, Harushige Kanno, Akira Itoh, Midori Sumitomo, Takashi Uchida, Atushi Kawabata, Chikashi Oiwa, Masamitsu Iwata, Toshinobu Horii, Shiomi Ishigo, Taira Yoshimura, Satoshi Ichiyama, Yasunao Wada, Satoshi Kimura, Shigefumi Maesaki, Kouichi Itoh, Yasunobu Noda, Takanori Yamashita, Ikuo Yamaguchi, Fumio Kageyama, Etsuko Shaku, Hisashi Baba, Kazuhisa Inuzuka, Hidetoshi Okabe, Kenichi Tatewaki, Kunihiko Moro, Masanori Aihara, Toshiharu Matsushima, Yoshihito Niki, Masao Kuw Abara, Siro Ikawa, Mobuaki Tanaka, Yasuharu Hinoda, Tetsuro Sugiura, Mikio Kamioka, Junko Ono, Tohru Takata, Hideichi Makino, Mitsuharu Murase, Hisashi Miyamoto, Hisamichi Aizawa, Junichi Honda, Masahide Takii, Zenzo Nagasawa, Yosuke Aoki, Naotaka Hamazaki, Toshiharu Tsutsui, Keiichi Nakagawa, Morihiro Iwata, Kazufumi Hiramatsu, Tetsunori Saikawa, Nobuhisa Yamane, Hiroya Kimoto, Tomio Kotani, Takeshi Kageoka, Toshiharu Hongo, Junichi Masuda, Hiroaki Miyanohara, Masayuki Tsujimura, Minoru Yasujima, Izumi Hayashi.
Abstract
The susceptibilities of bacteria to fluoroquinolones (FQs), especially levofloxacin, and other antimicrobial agents were investigated using 11,475 clinical isolates collected in Japan during 2002. Methicillin susceptible staphylococci, Streptococcus pyogenes, Streptococcus pneumoniae, Moraxella catarrhalis, the family of Enterobactericeae, Haemophilus influenzae and Acinetobacter spp. exhibited stable and high susceptibilities to FQs. The rate of FQs-resistant MRSA was 80 approximately 90%, being markedly higher than that of FQs-resistant MSSA. The FQs-resistance rate of MRCNS was also higher than that of MSCNS, however, it was lower than that of MRSA. No FQs-resistant clinical isolates of Salmonella spp. were detected in any of the surveys. Thirteen of Escherichai coli 696 isolates, 8 of Klebsiella pneumoniae 630 isolates and 33 of Proteus mirabilis 373 isolates produced extended-spectrum beta-lactamase (ESBL), furthermore 6 of 13 in E. coli, 1 of 8 in K. pneumoniae and 14 of 31 ESBL-producing isolates, and in P. mirabilis were FQs resistant. Attention should be focused in the future on the emergence of ESBL in relation to FQs resistance. The rate of FQs-resistant P. aeruginosa isolated from urinary tract infection (UTI) was 40 approximately 60%, while 15 approximately 25% of isolates from respiratory tract infection (RTI) were resistant. IMP-1 type metallo beta-lactamase producing organisms were found in 49 of P. aeruginosa 1,095 isolates, 7 of S. marcescens 586 isolates and 4 of Acinetobacter spp. 474 isolates, respectively. Glycopeptide-resistant enterococci or S. aureus was not found.Entities:
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Year: 2005 PMID： 15849869
Source DB: PubMed Journal: Jpn J Antibiot ISSN： 0368-2781