| Literature DB >> 15849773 |
Hui-Hua Hsiao1, Ming-Yu Yang, Yi-Chang Liu, Hui-Pin Hsiao, Shih-Bin Tseng, Mei-Chyn Chao, Ta-Chih Liu, Sheng-Fung Lin.
Abstract
The t(1;22)(p13;q13) is a nonrandom chromosomal abnormality in acute leukemia with the fusion oncogene, RBM15-MKL1 (OTT-MAL), identified recently. However, this abnormality has been described only in infants and young children with acute megakaryoblastic leukemia (AMKL). We report a 59-year-old male patient with the diagnosis of acute myeloid leukemia, subtype M1, who harbors an abnormal chromosome +der(1)t(1;22)(p13;q13). The RBM15-MKL1 (OTT-MAL) fusion transcript was also confirmed by the reverse transcriptase-polymerase chain reaction. This unusual abnormality is rare in adult cases of leukemia, and in children it is restricted to AMKL. This report is accompanied by a review of the literature on the t(1;22)(p13;q13). 2005 Wiley-Liss, Inc.Entities:
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Year: 2005 PMID： 15849773 DOI： 10.1002/ajh.20298
Source DB: PubMed Journal: Am J Hematol ISSN： 0361-8609 Impact factor: 10.047