Literature DB >> 15849389

Antithrombotic effect of captopril and enalapril in old rats.

Ewa Chabielska1, Andrzej Mogielnicki, Karol Kramkowski, Włodzimierz Buczko.   

Abstract

In the present study, we have shown considerably accelerated thrombosis in old rats in comparison with adult rats, which may be related to the impaired hemostatic balance in these animals. In old rats, captopril and enalapril caused a marked reduction of venous thrombus weight. The mechanism of antithrombotic action of these drugs seems to be dependent on the suppression of coagulation cascade and the enhancement of the fibrinolytic processes.

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Year:  2005        PMID： 15849389

Source DB:  PubMed          Journal:  Pharmacol Rep        ISSN： 1734-1140            Impact factor:   3.024


  3 in total

1.  Captopril and lisinopril decrease acetaldehyde effects upon the prothrombin time.

Authors:  Arthur S Brecher; Rachel Dubord
Journal:  Dig Dis Sci       Date:  2007-10-12       Impact factor: 3.199

2.  Quinapril decreases antifibrinolytic and prooxidative potential of propofol in arterial thrombosis in hypertensive rats.

Authors:  Marzena Wojewodzka-Zelezniakowicz; Wioleta Kisiel; Karol Kramkowski; Anna Gromotowicz-Poplawska; Agnieszka Zakrzeska; Adrian Stankiewicz; Patrycjusz Kolodziejczyk; Janusz Szemraj; Jerzy Robert Ladny; Ewa Chabielska
Journal:  J Renin Angiotensin Aldosterone Syst       Date:  2016-05-11       Impact factor: 1.636

3.  Angiotensin-converting enzyme inhibitors attenuate propofol-induced pro-oxidative and antifibrinolytic effect in human endothelial cells.

Authors:  Marzena Wojewodzka-Zelezniakowicz; Anna Gromotowicz-Poplawska; Wioleta Kisiel; Emilia Konarzewska; Janusz Szemraj; Jerzy Robert Ladny; Ewa Chabielska
Journal:  J Renin Angiotensin Aldosterone Syst       Date:  2017-01       Impact factor: 1.636
  3 in total

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