| Literature DB >> 15848793 |
Keith K Murai1, Elena B Pasquale.
Abstract
The Eph receptor tyrosine kinases and their ephrin ligands play a pivotal role during axon pathfinding and neural circuitry formation. A prominent way in which Eph receptors sculpt cellular morphology is by remodeling the actin cytoskeleton and the surrounding plasma membrane through the regulation of Rho family GTPases. Two articles in this issue of Neuron (Sahin et al. and Cowan et al.) shed light on how Eph receptors recruit guanine nucleotide exchange factors for Rho family GTPases to modulate growth cone dynamics.Entities:
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Year: 2005 PMID： 15848793 DOI： 10.1016/j.neuron.2005.04.004
Source DB: PubMed Journal: Neuron ISSN： 0896-6273 Impact factor: 17.173