| Literature DB >> 15848510 |
J Cicciarelli1, Y Cho, R Mateo, M El-Shahawy, Y Iwaki, R Selby.
Abstract
The UNOS donor population was examined from 1999 to 2002, and approximately 25% of the over 23,000 donors were biopsied (Bx). There was a significant trend (P < .001) of older donors, cardiovascular accident, and hypertension in the Bx group versus the non-Bx group. The percent GS was directly correlated (P < .001) to graft survival, delayed graft function, and primary nonfunction. Cox regression showed significant relative risk (RR) for >10% GS, hypertension, donors over the age of 50, and African American recipients. RR in donors with >10% GS could be ameliorated (P < .001) by choosing donors with <5 HLA-A, -B, or -DR mismatches (MM), or recipients who were nonsensitized, and/or first transplant. Risk should be managed in donors by choosing appropriate recipients and high-risk immunosuppresion protocols.Entities:
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Year: 2005 PMID： 15848510 DOI： 10.1016/j.transproceed.2004.12.108
Source DB: PubMed Journal: Transplant Proc ISSN： 0041-1345 Impact factor: 1.066