Literature DB >> 1584756

Alternative usage of initiation codons in mRNA encoding the cAMP-responsive-element modulator generates regulators with opposite functions.

V Delmas1, B M Laoide, D Masquilier, R P de Groot, N S Foulkes, P Sassone-Corsi.   

Abstract

The cAMP-responsive-element modulator (CREM) gene encodes both antagonists (CREM alpha/beta/gamma) and an activator (CREM tau) of cAMP-responsive transcription by alternative splicing. In adult mouse brain a predominant 21-kDa protein, not corresponding to any previously characterized transcript, is detected with specific CREM antibodies. A developmental switch occurs in brain as expression changes at birth from CREM alpha/beta to the 21-kDa protein. We show that the 21-kDa protein corresponds to S-CREM (short CREM), a protein produced by the use of an internal AUG initiation codon in the CREM tau transcript. S-CREM shares with the other CREM proteins the basic DNA-binding and leucine-zipper dimerization domain. S-CREM functions as a transcriptional repressor of cAMP-induced transcription. Thus, two proteins with opposite functions are generated by alternative translation using two AUG codons within the same reading frame.

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Year:  1992        PMID： 1584756      PMCID： PMC49054          DOI： 10.1073/pnas.89.10.4226

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  19 in total

1.  Characterization of motifs which are critical for activity of the cyclic AMP-responsive transcription factor CREB.

Authors:  G A Gonzalez; P Menzel; J Leonard; W H Fischer; M R Montminy
Journal:  Mol Cell Biol       Date:  1991-03       Impact factor: 4.272

Review 2.  More is better: activators and repressors from the same gene.

Authors:  N S Foulkes; P Sassone-Corsi
Journal:  Cell       Date:  1992-02-07       Impact factor: 41.582

3.  A single base deletion in the Tfm androgen receptor gene creates a short-lived messenger RNA that directs internal translation initiation.

Authors:  M L Gaspar; T Meo; P Bourgarel; J L Guenet; M Tosi
Journal:  Proc Natl Acad Sci U S A       Date:  1991-10-01       Impact factor: 11.205

4.  CREM gene: use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription.

Authors:  N S Foulkes; E Borrelli; P Sassone-Corsi
Journal:  Cell       Date:  1991-02-22       Impact factor: 41.582

5.  A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the same mRNA.

Authors:  P Descombes; U Schibler
Journal:  Cell       Date:  1991-11-01       Impact factor: 41.582

6.  Regulation of transcription by cyclic AMP-dependent protein kinase.

Authors:  P L Mellon; C H Clegg; L A Correll; G S McKnight
Journal:  Proc Natl Acad Sci U S A       Date:  1989-07       Impact factor: 11.205

7.  Subcellular fate of the int-2 oncoprotein is determined by choice of initiation codon.

Authors:  P Acland; M Dixon; G Peters; C Dickson
Journal:  Nature       Date:  1990-02-15       Impact factor: 49.962

8.  Induction of proto-oncogene fos transcription through the adenylate cyclase pathway: characterization of a cAMP-responsive element.

Authors:  P Sassone-Corsi; J Visvader; L Ferland; P L Mellon; I M Verma
Journal:  Genes Dev       Date:  1988-12       Impact factor: 11.361

9.  Identification of multiple nuclear factors that interact with cyclic adenosine 3',5'-monophosphate response element-binding protein and activating transcription factor-2 by protein-protein interactions.

Authors:  J P Hoeffler; J W Lustbader; C Y Chen
Journal:  Mol Endocrinol       Date:  1991-02

10.  The pim-1 oncogene encodes two related protein-serine/threonine kinases by alternative initiation at AUG and CUG.

Authors:  C J Saris; J Domen; A Berns
Journal:  EMBO J       Date:  1991-03       Impact factor: 11.598
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  36 in total

1.  DREAM-alphaCREM interaction via leucine-charged domains derepresses downstream regulatory element-dependent transcription.

Authors:  F Ledo; A M Carrión; W A Link; B Mellström; J R Naranjo
Journal:  Mol Cell Biol       Date:  2000-12       Impact factor: 4.272

2.  A novel intronic cAMP response element modulator (CREM) promoter is regulated by activator protein-1 (AP-1) and accounts for altered activation-induced CREM expression in T cells from patients with systemic lupus erythematosus.

Authors:  Thomas Rauen; Konrad Benedyk; Yuang-Taung Juang; Claus Kerkhoff; Vasileios C Kyttaris; Johannes Roth; George C Tsokos; Klaus Tenbrock
Journal:  J Biol Chem       Date:  2011-07-13       Impact factor: 5.157

3.  cAMP-response element modulator tau is a positive regulator of testis angiotensin converting enzyme transcription.

Authors:  Y Zhou; Z Sun; A R Means; P Sassone-Corsi; K E Bernstein
Journal:  Proc Natl Acad Sci U S A       Date:  1996-10-29       Impact factor: 11.205

Review 4.  Multiple steps in the regulation of transcription-factor level and activity.

Authors:  C F Calkhoven; G Ab
Journal:  Biochem J       Date:  1996-07-15       Impact factor: 3.857

5.  PU.1 can participate in an active enhancer complex without its transcriptional activation domain.

Authors:  J M Pongubala; M L Atchison
Journal:  Proc Natl Acad Sci U S A       Date:  1997-01-07       Impact factor: 11.205

6.  An isoform of transcription factor CREM expressed during spermatogenesis lacks the phosphorylation domain and represses cAMP-induced transcription.

Authors:  W H Walker; B M Sanborn; J F Habener
Journal:  Proc Natl Acad Sci U S A       Date:  1994-12-20       Impact factor: 11.205

7.  Identification of cyclic adenosine 3',5'-monophosphate response element modulator as an activator of the human sodium/iodide symporter upstream enhancer.

Authors:  Mike S Fenton; Kenneth M Marion; Jerome M Hershman
Journal:  Endocrinology       Date:  2008-01-17       Impact factor: 4.736

8.  dCREB2-mediated enhancement of memory formation.

Authors:  Thomas C Tubon; Jiabin Zhang; Eugenia L Friedman; Haining Jin; Erin D Gonzales; Hong Zhou; Diana Drier; Jason R Gerstner; Emily A Paulson; Robin Fropf; Jerry C P Yin
Journal:  J Neurosci       Date:  2013-04-24       Impact factor: 6.167

9.  Identification of human T-cell lymphotropic virus type I 21-base-pair repeat-specific and glial cell-specific DNA-protein complexes.

Authors:  M Tillmann; R Wessner; B Wigdahl
Journal:  J Virol       Date:  1994-07       Impact factor: 5.103

10.  The A2A adenosine receptor is a dual coding gene: a novel mechanism of gene usage and signal transduction.

Authors:  Chien-fei Lee; Hsin-Lin Lai; Yi-Chao Lee; Chen-Li Chien; Yijuang Chern
Journal:  J Biol Chem       Date:  2013-11-29       Impact factor: 5.157
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