Literature DB >> 15845529

Regulation of the mitogen-activated protein kinases by Brucella spp. expressing a smooth and rough phenotype: relationship to pathogen invasiveness.

María P Jiménez de Bagüés1, Antoine Gross, Annie Terraza, Jacques Dornand.   

Abstract

By comparing smooth wild-type Brucella spp. to their rough mutants, we show that the LPS O chain restricted the activation of the ERK1/2 and p38 mitogen-activated protein kinase (MAPK) pathways, thus preventing the synthesis of immune mediators that regulate host defense. We conclude that the MAPKs are a target for immune intervention by virulent smooth Brucella.

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Year:  2005        PMID： 15845529      PMCID： PMC1087367          DOI： 10.1128/IAI.73.5.3178-3183.2005

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  50 in total

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Journal:  J Biol Chem       Date:  2001-02-13       Impact factor: 5.157

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Authors:  J E Ugalde; C Czibener; M F Feldman; R A Ugalde
Journal:  Infect Immun       Date:  2000-10       Impact factor: 3.441

3.  High levels of nitric oxide production decrease early but increase late survival of Brucella abortus in macrophages.

Authors:  M Wang; N Qureshi; N Soeurt; G Splitter
Journal:  Microb Pathog       Date:  2001-11       Impact factor: 3.738

4.  Deletion of wboA enhances activation of the lectin pathway of complement in Brucella abortus and Brucella melitensis.

Authors:  C M Fernandez-Prada; M Nikolich; R Vemulapalli; N Sriranganathan; S M Boyle; G G Schurig; T L Hadfield; D L Hoover
Journal:  Infect Immun       Date:  2001-07       Impact factor: 3.441

5.  GTPases of the Rho subfamily are required for Brucella abortus internalization in nonprofessional phagocytes: direct activation of Cdc42.

Authors:  C Guzmán-Verri; E Chaves-Olarte; C von Eichel-Streiber; I López-Goñi; M Thelestam; S Arvidson; J P Gorvel; E Moreno
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6.  The polysaccharide portion plays an indispensable role in Salmonella lipopolysaccharide-induced activation of NF-kappaB through human toll-like receptor 4.

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7.  Differential regulation of the mitogen-activated protein kinases by pathogenic and nonpathogenic mycobacteria.

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Review 8.  Stat1-dependent and -independent pathways in IFN-gamma-dependent signaling.

Authors:  Chilakamarti V Ramana; M Pilar Gil; Robert D Schreiber; George R Stark
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9.  Evidence for a p21(ras)/Raf-1/MEK-1/ERK-2-independent pathway in stimulation of IL-2 gene transcription in human primary T lymphocytes.

Authors:  V Lafont; F Ottones; J Liautard; J Favero
Journal:  J Biol Chem       Date:  1999-09-03       Impact factor: 5.157

10.  Intracellular survival of Brucella spp. in human monocytes involves conventional uptake but special phagosomes.

Authors:  M G Rittig; M T Alvarez-Martinez; F Porte; J P Liautard; B Rouot
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  14 in total

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Authors:  Gireesh Rajashekara; David A Glover; Menachem Banai; David O'Callaghan; Gary A Splitter
Journal:  Infect Immun       Date:  2006-05       Impact factor: 3.441

2.  Evaluation of protection afforded by Brucella abortus and Brucella melitensis unmarked deletion mutants exhibiting different rates of clearance in BALB/c mice.

Authors:  M M Kahl-McDonagh; T A Ficht
Journal:  Infect Immun       Date:  2006-07       Impact factor: 3.441

3.  High susceptibility of human dendritic cells to invasion by the intracellular pathogens Brucella suis, B. abortus, and B. melitensis.

Authors:  Elisabeth Billard; Chantal Cazevieille; Jacques Dornand; Antoine Gross
Journal:  Infect Immun       Date:  2005-12       Impact factor: 3.441

4.  Enhancing the role of veterinary vaccines reducing zoonotic diseases of humans: linking systems biology with vaccine development.

Authors:  L Garry Adams; Sangeeta Khare; Sara D Lawhon; Carlos A Rossetti; Harris A Lewin; Mary S Lipton; Joshua E Turse; Dennis C Wylie; Yu Bai; Kenneth L Drake
Journal:  Vaccine       Date:  2011-06-07       Impact factor: 3.641

5.  A Chemical Genetics Screen Reveals Influence of p38 Mitogen-Activated Protein Kinase and Autophagy on Phagosome Development and Intracellular Replication of Brucella neotomae in Macrophages.

Authors:  Yoon-Suk Kang; James E Kirby
Journal:  Infect Immun       Date:  2019-07-23       Impact factor: 3.441

6.  TLR2 signaling subpathways regulate TLR9 signaling for the effective induction of IL-12 upon stimulation by heat-killed Brucella abortus.

Authors:  Chun-Yan Zhang; Nan Bai; Zhu-Hong Zhang; Ning Liang; Lan Dong; Rong Xiang; Cheng-Hu Liu
Journal:  Cell Mol Immunol       Date:  2012-05-28       Impact factor: 11.530

7.  Transcriptome analysis of HeLa cells response to Brucella melitensis infection: a molecular approach to understand the role of the mucosal epithelium in the onset of the Brucella pathogenesis.

Authors:  Carlos A Rossetti; Kenneth L Drake; L Garry Adams
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8.  Genomic island 2 of Brucella melitensis is a major virulence determinant: functional analyses of genomic islands.

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9.  Interaction of Brucella suis and Brucella abortus rough strains with human dendritic cells.

Authors:  Elisabeth Billard; Jacques Dornand; Antoine Gross
Journal:  Infect Immun       Date:  2007-10-15       Impact factor: 3.441

Review 10.  The role of innate immune signals in immunity to Brucella abortus.

Authors:  Marco Túlio R Gomes; Priscila C Campos; Leonardo A de Almeida; Fernanda S Oliveira; Miriam Maria S Costa; Fernanda M Marim; Guilherme S M Pereira; Sergio C Oliveira
Journal:  Front Cell Infect Microbiol       Date:  2012-10-25       Impact factor: 5.293
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