Literature DB >> 15845424

The dopamine transporter: role in neurotoxicity and human disease.

Michael J Bannon1.   

Abstract

The dopamine transporter (DAT) is a plasma membrane transport protein expressed exclusively within a small subset of CNS neurons. It plays a crucial role in controlling dopamine-mediated neurotransmission and a number of associated behaviors. This review focuses on recent data elucidating the role of the dopamine transporter in neurotoxicity and a number of CNS disorders, including Parkinson disease, drug abuse, and attention deficit hyperactivity disorder (ADHD).

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Year:  2005        PMID： 15845424     DOI： 10.1016/j.taap.2004.08.013

Source DB:  PubMed          Journal:  Toxicol Appl Pharmacol        ISSN： 0041-008X            Impact factor:   4.219


  32 in total

Review 1.  Recognition of psychostimulants, antidepressants, and other inhibitors of synaptic neurotransmitter uptake by the plasma membrane monoamine transporters.

Authors:  Christopher K Surratt; Okechukwu T Ukairo; Suneetha Ramanujapuram
Journal:  AAPS J       Date:  2005-10-27       Impact factor: 4.009

Review 2.  Maternal separation alters drug intake patterns in adulthood in rats.

Authors:  M C Moffett; A Vicentic; Marie Kozel; Paul Plotsky; D D Francis; M J Kuhar
Journal:  Biochem Pharmacol       Date:  2006-09-08       Impact factor: 5.858

3.  DAT1 Gene Methylation as an Epigenetic Biomarker in Attention Deficit Hyperactivity Disorder: A Commentary.

Authors:  Erika Tonelli; Esterina Pascale; Miriam Troianiello; Claudio D'Addario; Walter Adriani
Journal:  Front Genet       Date:  2020-05-11       Impact factor: 4.599

Review 4.  Reducing safety-related drug attrition: the use of in vitro pharmacological profiling.

Authors:  Joanne Bowes; Andrew J Brown; Jacques Hamon; Wolfgang Jarolimek; Arun Sridhar; Gareth Waldron; Steven Whitebread
Journal:  Nat Rev Drug Discov       Date:  2012-12       Impact factor: 84.694

Review 5.  Challenges and recent advances in mass spectrometric imaging of neurotransmitters.

Authors:  Erin Gemperline; Bingming Chen; Lingjun Li
Journal:  Bioanalysis       Date:  2014-02       Impact factor: 2.681

6.  Potential for diagnosis versus therapy monitoring of attention deficit hyperactivity disorder: a new epigenetic biomarker interacting with both genotype and auto-immunity.

Authors:  Walter Adriani; Emilia Romano; Mariangela Pucci; Esterina Pascale; Luca Cerniglia; Silvia Cimino; Renata Tambelli; Paolo Curatolo; Oleg Granstrem; Mauro Maccarrone; Giovanni Laviola; Claudio D'Addario
Journal:  Eur Child Adolesc Psychiatry       Date:  2017-08-18       Impact factor: 4.785

7.  The rare DAT coding variant Val559 perturbs DA neuron function, changes behavior, and alters in vivo responses to psychostimulants.

Authors:  Marc A Mergy; Raajaram Gowrishankar; Paul J Gresch; Stephanie C Gantz; John Williams; Gwynne L Davis; C Austin Wheeler; Gregg D Stanwood; Maureen K Hahn; Randy D Blakely
Journal:  Proc Natl Acad Sci U S A       Date:  2014-10-20       Impact factor: 11.205

8.  Interaction of catechol and non-catechol substrates with externally or internally facing dopamine transporters.

Authors:  Ying-Jian Liang; Juan Zhen; Nianhang Chen; Maarten E A Reith
Journal:  J Neurochem       Date:  2009-03-11       Impact factor: 5.372

9.  Functional analysis of upstream common polymorphisms of the dopamine transporter gene.

Authors:  Mikhil N Bamne; Michael E Talkowski; Kodavali V Chowdari; Vishwajit L Nimgaonkar
Journal:  Schizophr Bull       Date:  2009-03-09       Impact factor: 9.306

10.  Dopamine-mediated autocrine inhibitory circuit regulating human insulin secretion in vitro.

Authors:  Norman Simpson; Antonella Maffei; Matthew Freeby; Steven Burroughs; Zachary Freyberg; Jonathan Javitch; Rudolph L Leibel; Paul E Harris
Journal:  Mol Endocrinol       Date:  2012-08-21
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