| Literature DB >> 15844962 |
Chaowei Zhang1, John G Ondeyka, Kithsiri B Herath, Ziqiang Guan, Javier Collado, Gonzalo Platas, Fernando Pelaez, Penny S Leavitt, Anne Gurnett, Bakela Nare, Paul Liberator, Sheo B Singh.
Abstract
Parasite cGMP-dependent protein kinase (PKG) has been recently validated as a biochemical target for the treatment of coccidiosis. To discover new anticoccidial leads, we have screened our library of natural product extracts for inhibitors of parasite PKG. Bioassay-guided fractionation of the microbial extracts has led to the discovery of tenellones A (2) and B (3), two new highly substituted benzophenones. The isolation, structure, and activity of these compounds are described.Entities:
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Year: 2005 PMID： 15844962 DOI： 10.1021/np049591n
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050