Literature DB >> 15844951

Cremastrine, a pyrrolizidine alkaloid from Cremastra appendiculata.

Yoshitaka Ikeda1, Hikaru Nonaka, Tamotsu Furumai, Yasuhiro Igarashi.   

Abstract

A new pyrrolizidine alkaloid, cremastrine (1), was isolated from the bulbs of Cremastra appendiculata. Its configuration was determined by spectroscopic and chemical analyses. Compound 1 inhibited the binding of tritium-labeled N-methylscopolamine to the muscarinic M3 receptor with a K(i) value of 126 nM.

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Year:  2005        PMID： 15844951     DOI： 10.1021/np049650x

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  6 in total

1.  Synthesis and Biological Evaluation of Cremastrine and an Unnatural Analogue.

Authors:  Kristopher N Hahn; Olugbeminiyi O Fadeyi; Hyekyung P Cho; Craig W Lindsley
Journal:  Tetrahedron Lett       Date:  2012-05-10       Impact factor: 2.415

2.  Screening of endophytic fungi from Cremastra appendiculata and their potential for plant growth promotion and biological control.

Authors:  Siyu Wang; Senmiao Chen; Bixu Wang; Qianxi Li; Jiaqi Zu; Jie Yu; Zhishan Ding; Fangmei Zhou
Journal:  Folia Microbiol (Praha)       Date:  2022-08-19       Impact factor: 2.629

3.  Synthesis and mechanistic studies of a novel homoisoflavanone inhibitor of endothelial cell growth.

Authors:  Halesha D Basavarajappa; Bit Lee; Xiang Fei; Daesung Lim; Breedge Callaghan; Julie A Mund; Jamie Case; Gangaraju Rajashekhar; Seung-Yong Seo; Timothy W Corson
Journal:  PLoS One       Date:  2014-04-21       Impact factor: 3.240

4.  Zinc-Catalyzed Enantioselective [3+2] Cycloaddition of Azomethine Ylides Using Planar Chiral [2.2]Paracyclophane-Imidazoline N,O-ligands.

Authors:  Sundaravel Vivek Kumar; Patrick J Guiry
Journal:  Angew Chem Int Ed Engl       Date:  2022-06-09       Impact factor: 16.823

5.  Transcriptome Profiles Reveal the Crucial Roles of Auxin and Cytokinin in the "Shoot Branching" of Cremastra appendiculata.

Authors:  Xiang Lv; Mingsheng Zhang; Xiaolan Li; Ruihua Ye; Xiaohong Wang
Journal:  Int J Mol Sci       Date:  2018-10-26       Impact factor: 5.923

Review 6.  Pyrrolizidine Alkaloids: Biosynthesis, Biological Activities and Occurrence in Crop Plants.

Authors:  Sebastian Schramm; Nikolai Köhler; Wilfried Rozhon
Journal:  Molecules       Date:  2019-01-30       Impact factor: 4.411
  6 in total

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