Literature DB >> 15844898

Facile and convenient syntheses of 6,11-dihydro-5H-indeno[1,2-c]isoquinolin- 5-ones and 6,11-dihydro-5H-indolo[3,2-c]isoquinolin-5-one.

Prakash G Jagtap1, Erkan Baloglu, Garry Southan, William Williams, Aloka Roy, Alexander Nivorozhkin, Nelson Landrau, Kevin Desisto, Andrew L Salzman, Csaba Szabó.   

Abstract

[reaction: see text] The synthesis of 6,11-dihydro-5H-indeno[1,2-c]isoquinolin-5-ones from the base-promoted condensation reaction of homophthalic anhydride and 2-(bromomethyl)-benzonitrile and a convenient method for the synthesis of indolo[3,2-c]isoquinolinones are described.

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Year:  2005        PMID： 15844898     DOI： 10.1021/ol050331m

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  5 in total

1.  7-azaindenoisoquinolines as topoisomerase I inhibitors and potential anticancer agents.

Authors:  Evgeny Kiselev; Sean DeGuire; Andrew Morrell; Keli Agama; Thomas S Dexheimer; Yves Pommier; Mark Cushman
Journal:  J Med Chem       Date:  2011-08-08       Impact factor: 7.446

2.  Azaindenoisoquinolines as topoisomerase I inhibitors and potential anticancer agents: a systematic study of structure-activity relationships.

Authors:  Evgeny Kiselev; Keli Agama; Yves Pommier; Mark Cushman
Journal:  J Med Chem       Date:  2012-02-13       Impact factor: 7.446

3.  Sequential Cu(I)/Pd(0)-catalyzed multicomponent coupling and annulation protocol for the synthesis of indenoisoquinolines.

Authors:  Thiruvellore Thatai Jayanth; Lei Zhang; Thomas S Johnson; Helena C Malinakova
Journal:  Org Lett       Date:  2009-02-19       Impact factor: 6.005

4.  Zinc oxide nanoparticles catalyzed condensation reaction of isocoumarins and 1,7-heptadiamine in the formation of bis-isoquinolinones.

Authors:  Varadhan Krishnakumar; Kesarla Mohan Kumar; Badal Kumar Mandal; Fazlur-Rahman Nawaz Khan
Journal:  ScientificWorldJournal       Date:  2012-03-12

5.  Two Annulated Azaheterocyclic Cores Readily Available from a Single Tetrahydroisoquinolonic Castagnoli-Cushman Precursor.

Authors:  Elizaveta Karchuganova; Olga Bakulina; Dmitry Dar'in; Mikhail Krasavin
Journal:  Molecules       Date:  2020-04-28       Impact factor: 4.411
  5 in total

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