| Literature DB >> 15843046 |
Ruither O G Carolino1, Renê O Beleboni, Andrea B Pizzo, Flavio Del Vecchio, Norberto Garcia-Cairasco, Miguel Moyses-Neto, Wagner F Dos Santos, Joaquim Coutinho-Netto.
Abstract
We obtained a neurotoxic fraction (AcTx) from star fruit (Averrhoa carambola) and studied its effects on GABAergic and glutamatergic transmission systems. AcTx had no effect on GABA/glutamate uptake or release, or on glutamate binding. However, it specifically inhibited GABA binding in a concentration-dependent manner (IC(50)=0.89muM). Video-electroencephalogram recordings demonstrated that following cortical administration of AcTx, animals showed behavioral changes, including tonic-clonic seizures, evolving into status epilepticus, accompanied by cortical epileptiform activity. Chemical characterization of AcTx showed that this compound is a nonproteic molecule with a molecular weight less than 500, differing from oxalic acid. This neurotoxic fraction of star fruit may be considered a new tool for neurochemical and neuroethological research.Entities:
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Year: 2005 PMID： 15843046 DOI： 10.1016/j.neuint.2005.02.002
Source DB: PubMed Journal: Neurochem Int ISSN： 0197-0186 Impact factor: 3.921