Literature DB >> 15842661

Aberrant somatic hypermutation and expression of activation-induced cytidine deaminase mRNA in mediastinal large B-cell lymphoma.

Csaba Bödör1, Agnes Bognár, Lilla Reiniger, Agota Szepesi, Erika Tóth, László Kopper, András Matolcsy.   

Abstract

To determine the possible role of aberrant somatic hypermutation (ASHM) and activation-induced cytidine deaminase (AID) expression in the pathogenesis of mediastinal large B-cell lymphoma (MBL), the mutational status of genes affected by ASHM, including c-MYC, PAX-5 and RhoH, was analysed, and the expression level of AID mRNA in tumour specimens from six patients with MBL was determined. Mutations in one or more genes and high expression of AID mRNA were detected in all the six cases of MBL. These results suggest that ASHM and AID expression may have a role in the pathogenesis of MBL.

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Year:  2005        PMID： 15842661     DOI： 10.1111/j.1365-2141.2005.05454.x

Source DB:  PubMed          Journal:  Br J Haematol        ISSN： 0007-1048            Impact factor:   6.998


  7 in total

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Journal:  Blood       Date:  2014-12-01       Impact factor: 22.113

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Review 7.  Impact of the microenvironment on the pathogenesis of mucosa-associated lymphoid tissue lymphomas.

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  7 in total

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