Practical retinoid chemoprophylaxis in solid organ transplant recipients.

Solid organ transplant recipients are at a significantly increased risk of developing skin cancer. Both systemic and topical retinoids are useful for chemosuppression of skin cancer in this patient population. These drugs can reduce both the present extent and the future development of premalignant and malignant skin lesions. This paper reviews the current data on the chemoprophylactic properties of topical and systemic retinoids. A practical guide for their use in organ transplant recipients is provided. Specific recommendations for implementing and maintaining therapy, as well as appropriate management and monitoring of adverse events, are presented.