Literature DB >> 1584235

When did Ray Kennedy's Parkinson's disease begin?

A J Lees1.   

Abstract

Ray Kennedy's Parkinson's disease probably began during his distinguished career as a professional soccer player at least 10 years before the first unequivocal physical signs and 14 years before the diagnosis was finally made, when he was 35-years old. Early prodromal symptoms included intermittent subtle disturbances of movement and posture affecting the right arm and leg, mild facial immobility, episodes of profound malaise and lack of energy, inner feelings of tremulousness, excessive unprovoked bouts of perspiration, and accompanying feelings of heat. Abnormalities of movement in the right arm can be seen in video footage of soccer games up to 8 years before his disability came to medical attention. Many of his premorbid personality traits are characteristic of those believed to be associated with the subsequent development of the malady. At least in some patients with Parkinson's disease, the search for instigating aetiological factors should focus 10-20 years before the cardinal signs can be recognised with certainty.

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Mesh:

Year:  1992        PMID: 1584235     DOI: 10.1002/mds.870070203

Source DB:  PubMed          Journal:  Mov Disord        ISSN: 0885-3185            Impact factor:   10.338


  20 in total

1.  Protein expression in a Drosophila model of Parkinson's disease.

Authors:  Zhiyin Xun; Renã A Sowell; Thomas C Kaufman; David E Clemmer
Journal:  J Proteome Res       Date:  2007-01       Impact factor: 4.466

2.  Changes in brain functional activation during resting and locomotor states after unilateral nigrostriatal damage in rats.

Authors:  J Yang; T R Sadler; T K Givrad; J-M I Maarek; D P Holschneider
Journal:  Neuroimage       Date:  2007-03-23       Impact factor: 6.556

3.  Substantia nigra hyperechogenicity in depressive subjects relates to motor asymmetry and impaired word fluency.

Authors:  Jacqueline Hoeppner; Lara Prudente-Morrissey; Sabine Christiane Herpertz; Reiner Benecke; Uwe Walter
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  2008-09-19       Impact factor: 5.270

4.  A Brazilian Football Player Still on the Pitch After 10 Years of Parkinson's Disease with Severe Freezing of Gait.

Authors:  Thiago Cardoso Vale; José Luiz Pedroso; Orlando Graziani Barsottini; Andrew John Lees
Journal:  Mov Disord Clin Pract       Date:  2014-12-06

5.  Transcranial sonography of the substantia nigra: digital image analysis.

Authors:  D Skoloudík; M Jelínková; J Blahuta; P Cermák; T Soukup; P Bártová; K Langová; R Herzig
Journal:  AJNR Am J Neuroradiol       Date:  2014-07-24       Impact factor: 3.825

6.  ELECTRONIC PLATFORM MEASURES OF BALANCE IMPAIRMENT IN PARKINSONIANS AND FIRST DEGREE RELATIVES.

Authors:  Gregory M Constantine; Nicolaas I Bohnen; Carson C Chow
Journal:  Int J Pure Appl Math       Date:  2004

7.  Forced limb-use effects on the behavioral and neurochemical effects of 6-hydroxydopamine.

Authors:  J L Tillerson; A D Cohen; J Philhower; G W Miller; M J Zigmond; T Schallert
Journal:  J Neurosci       Date:  2001-06-15       Impact factor: 6.167

Review 8.  Neurological disorders of gait, balance and posture: a sign-based approach.

Authors:  Jorik Nonnekes; Rianne J M Goselink; Evžen Růžička; Alfonso Fasano; John G Nutt; Bastiaan R Bloem
Journal:  Nat Rev Neurol       Date:  2018-01-29       Impact factor: 42.937

Review 9.  Proteomics in animal models of Alzheimer's and Parkinson's diseases.

Authors:  Renã A Sowell; Joshua B Owen; D Allan Butterfield
Journal:  Ageing Res Rev       Date:  2008-07-18       Impact factor: 10.895

Review 10.  Idiopathic Parkinson's disease: epidemiology, diagnosis and management.

Authors:  Y Ben-Shlomo; K Sieradzan
Journal:  Br J Gen Pract       Date:  1995-05       Impact factor: 5.386

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