| Literature DB >> 15840399 |
Javad Sajedianfard1, Shohreh Khatami, Saeed Semnanian, Naser Naghdi, Masomeh Jorjani.
Abstract
The locus coeruleus is involved in the regulation of the sense of pain. To demonstrate the changes in noradrenaline level in the locus coeruleus during the formalin test, a microdialysis probe was implanted into the left locus coeruleus of rats. Formalin was subcutaneously injected into the plantar surface of the right hind paw and pain ratings were recorded. The concentrations of noradrenaline and its metabolite 3-methoxy-4-hydroxyphenylethylenglycol (MHPG) were measured. The results showed an almost four-fold elevation in noradrenaline release in the early phase of the formalin test; levels return to baseline in the late phase. Levels of MHPG changed in a similar fashion.Entities:
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Year: 2005 PMID： 15840399 DOI： 10.1016/j.ejphar.2005.02.032
Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432