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Literature DB >> 15837542

Combinations of polymorphisms in XPD, XPC and XPA in relation to risk of lung cancer.

Ulla Vogel¹, Kim Overvad, Håkan Wallin, Anne Tjønneland, Bjørn A Nexø, Ole Raaschou-Nielsen.

Abstract

Inherited polymorphisms in DNA repair genes may contribute to genetic susceptibility to cancer. XPA, XPC and XPD all encode proteins that are part of the nucleotide excision repair pathway. In a nested case-cohort study, we have investigated the occurrence of lung cancer in relation to commonly occurring polymorphisms in XPA, XPC and XPD. Among 54,220 members of a Danish prospective cohort study, 265 lung cancer cases were identified and a sub-cohort comprising 272 individuals was used for comparison. We found that XPA A23G and XPC Lys939Gln polymorphisms may be risk factors for lung cancer and evidence that positive interactions between the polymorphisms in XPA/XPD and XPC/XPD may occur.

Entities: Disease Gene Mutation

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Substances：

Year: 2005 PMID： 15837542 DOI： 10.1016/j.canlet.2004.11.016

Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679

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Cited

34 in total

1. XPA A23G polymorphism and susceptibility to cancer: a meta-analysis.

Authors: Jun Liu; Zhen Zhang; Xiao-Lin Cao; Da-Peng Lei; Zhong-Qiu Wang; Tong Jin; Xin-Liang Pan
Journal: Mol Biol Rep Date: 2012-06 Impact factor: 2.316

2. Modulation of DNA damage/DNA repair capacity by XPC polymorphisms.

Authors: Yimin Zhu; Hushan Yang; Qin Chen; Jie Lin; H Barton Grossman; Colin P Dinney; Xifeng Wu; Jian Gu
Journal: DNA Repair (Amst) Date: 2007-10-17

Review 3. Host nucleotide polymorphism in hepatitis B virus-associated hepatocellular carcinoma.

Authors: Shilu Mathew; Hany Abdel-Hafiz; Abbas Raza; Kaneez Fatima; Ishtiaq Qadri
Journal: World J Hepatol Date: 2016-04-08

4. Hodgkin lymphoma risk: role of genetic polymorphisms and gene-gene interactions in DNA repair pathways.

Authors: Claudia M Monroy; Andrea C Cortes; Mirtha Lopez; Elizabeth Rourke; Carol J Etzel; Anas Younes; Sara S Strom; Randa El-Zein
Journal: Mol Carcinog Date: 2011-03-03 Impact factor: 4.784

5. XPA A23G polymorphism and lung cancer risk: a meta-analysis.

Authors: Ji-Hong Zou; Li An; Shi Chen; Li-Qun Ren
Journal: Mol Biol Rep Date: 2011-05-25 Impact factor: 2.316

6. Functional analysis of Rad14p, a DNA damage recognition factor in nucleotide excision repair, in regulation of transcription in vivo.

Authors: Priyasri Chaurasia; Rwik Sen; Sukesh R Bhaumik
Journal: J Biol Chem Date: 2012-11-27 Impact factor: 5.157

Combinations of polymorphisms in XPD, XPC and XPA in relation to risk of lung cancer.

1. XPA A23G polymorphism and susceptibility to cancer: a meta-analysis.

2. Modulation of DNA damage/DNA repair capacity by XPC polymorphisms.

Review 3. Host nucleotide polymorphism in hepatitis B virus-associated hepatocellular carcinoma.

4. Hodgkin lymphoma risk: role of genetic polymorphisms and gene-gene interactions in DNA repair pathways.

5. XPA A23G polymorphism and lung cancer risk: a meta-analysis.

6. Functional analysis of Rad14p, a DNA damage recognition factor in nucleotide excision repair, in regulation of transcription in vivo.

7. A meta-analysis of evidences on XPC polymorphisms and lung cancer susceptibility.

8. Using haplotype analysis to elucidate significant associations between genes and Hodgkin lymphoma.

9. Lung cancer risk and genetic polymorphisms in DNA repair pathways: a meta-analysis.

10. Genetic polymorphisms in DNA repair genes as modulators of Hodgkin disease risk.